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Inducible mismatch repair streamlines forward genetic approaches to target identification of cytotoxic small molecules.
Nguyen TP, Fang M, Kim J, Wang B, Lin E, Khivansara V, Barrows N, Rivera-Cancel G, Goralski M, Cervantes CL, Xie S, Peterson JM, Povedano JM, Antczak MI, Posner BA, Harvey CJB, Naughton BT, McFadden DG, Ready JM, De Brabander JK, Nijhawan D. Nguyen TP, et al. Among authors: nijhawan d. Cell Chem Biol. 2023 Nov 16;30(11):1453-1467.e8. doi: 10.1016/j.chembiol.2023.07.017. Epub 2023 Aug 21. Cell Chem Biol. 2023. PMID: 37607550
Discovery of tumor-specific irreversible inhibitors of stearoyl CoA desaturase.
Theodoropoulos PC, Gonzales SS, Winterton SE, Rodriguez-Navas C, McKnight JS, Morlock LK, Hanson JM, Cross B, Owen AE, Duan Y, Moreno JR, Lemoff A, Mirzaei H, Posner BA, Williams NS, Ready JM, Nijhawan D. Theodoropoulos PC, et al. Among authors: nijhawan d. Nat Chem Biol. 2016 Apr;12(4):218-25. doi: 10.1038/nchembio.2016. Epub 2016 Feb 1. Nat Chem Biol. 2016. PMID: 26829472 Free PMC article.
The antitumor toxin CD437 is a direct inhibitor of DNA polymerase α.
Han T, Goralski M, Capota E, Padrick SB, Kim J, Xie Y, Nijhawan D. Han T, et al. Among authors: nijhawan d. Nat Chem Biol. 2016 Jul;12(7):511-5. doi: 10.1038/nchembio.2082. Epub 2016 May 16. Nat Chem Biol. 2016. PMID: 27182663 Free PMC article.
Selective targeting of mutant adenomatous polyposis coli (APC) in colorectal cancer.
Zhang L, Theodoropoulos PC, Eskiocak U, Wang W, Moon YA, Posner B, Williams NS, Wright WE, Kim SB, Nijhawan D, De Brabander JK, Shay JW. Zhang L, et al. Among authors: nijhawan d. Sci Transl Med. 2016 Oct 19;8(361):361ra140. doi: 10.1126/scitranslmed.aaf8127. Sci Transl Med. 2016. PMID: 27798265 Free PMC article.
36 results