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Disrupting Roquin-1 interaction with Regnase-1 induces autoimmunity and enhances antitumor responses.
Behrens G, Edelmann SL, Raj T, Kronbeck N, Monecke T, Davydova E, Wong EH, Kifinger L, Giesert F, Kirmaier ME, Hohn C, de Jonge LS, Pisfil MG, Fu M, Theurich S, Feske S, Kawakami N, Wurst W, Niessing D, Heissmeyer V. Behrens G, et al. Among authors: niessing d. Nat Immunol. 2021 Dec;22(12):1563-1576. doi: 10.1038/s41590-021-01064-3. Epub 2021 Nov 22. Nat Immunol. 2021. PMID: 34811541 Free PMC article.
RNA recognition by Roquin in posttranscriptional gene regulation.
Schlundt A, Niessing D, Heissmeyer V, Sattler M. Schlundt A, et al. Among authors: niessing d. Wiley Interdiscip Rev RNA. 2016 Jul;7(4):455-69. doi: 10.1002/wrna.1333. Epub 2016 Feb 4. Wiley Interdiscip Rev RNA. 2016. PMID: 26844532 Review.
Roquin recognizes a non-canonical hexaloop structure in the 3'-UTR of Ox40.
Janowski R, Heinz GA, Schlundt A, Wommelsdorf N, Brenner S, Gruber AR, Blank M, Buch T, Buhmann R, Zavolan M, Niessing D, Heissmeyer V, Sattler M. Janowski R, et al. Among authors: niessing d. Nat Commun. 2016 Mar 24;7:11032. doi: 10.1038/ncomms11032. Nat Commun. 2016. PMID: 27010430 Free PMC article.
Binding of NUFIP2 to Roquin promotes recognition and regulation of ICOS mRNA.
Rehage N, Davydova E, Conrad C, Behrens G, Maiser A, Stehklein JE, Brenner S, Klein J, Jeridi A, Hoffmann A, Lee E, Dianzani U, Willemsen R, Feederle R, Reiche K, Hackermüller J, Leonhardt H, Sharma S, Niessing D, Heissmeyer V. Rehage N, et al. Among authors: niessing d. Nat Commun. 2018 Jan 19;9(1):299. doi: 10.1038/s41467-017-02582-1. Nat Commun. 2018. PMID: 29352114 Free PMC article.
Human TRMT2A methylates tRNA and contributes to translation fidelity.
Witzenberger M, Burczyk S, Settele D, Mayer W, Welp LM, Heiss M, Wagner M, Monecke T, Janowski R, Carell T, Urlaub H, Hauck SM, Voigt A, Niessing D. Witzenberger M, et al. Among authors: niessing d. Nucleic Acids Res. 2023 Sep 8;51(16):8691-8710. doi: 10.1093/nar/gkad565. Nucleic Acids Res. 2023. PMID: 37395448 Free PMC article.
PURA syndrome-causing mutations impair PUR-domain integrity and affect P-body association.
Proske M, Janowski R, Bacher S, Kang HS, Monecke T, Koehler T, Hutten S, Tretter J, Crois A, Molitor L, Varela-Rial A, Fino R, Donati E, De Fabritiis G, Dormann D, Sattler M, Niessing D. Proske M, et al. Among authors: niessing d. Elife. 2024 Apr 24;13:RP93561. doi: 10.7554/eLife.93561. Elife. 2024. PMID: 38655849 Free PMC article.
Small-molecule modulators of TRMT2A decrease PolyQ aggregation and PolyQ-induced cell death.
Margreiter MA, Witzenberger M, Wasser Y, Davydova E, Janowski R, Metz J, Habib P, Sahnoun SEM, Sobisch C, Poma B, Palomino-Hernandez O, Wagner M, Carell T, Jon Shah N, Schulz JB, Niessing D, Voigt A, Rossetti G. Margreiter MA, et al. Among authors: niessing d. Comput Struct Biotechnol J. 2021 Dec 28;20:443-458. doi: 10.1016/j.csbj.2021.12.029. eCollection 2022. Comput Struct Biotechnol J. 2021. PMID: 35070167 Free PMC article.
68 results