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Integrative analysis of neuroblastoma by single-cell RNA sequencing identifies the NECTIN2-TIGIT axis as a target for immunotherapy.
Wienke J, Visser LL, Kholosy WM, Keller KM, Barisa M, Poon E, Munnings-Tomes S, Himsworth C, Calton E, Rodriguez A, Bernardi R, van den Ham F, van Hooff SR, Matser YAH, Tas ML, Langenberg KPS, Lijnzaad P, Borst AL, Zappa E, Bergsma FJ, Strijker JGM, Verhoeven BM, Mei S, Kramdi A, Restuadi R, Sanchez-Bernabeu A, Cornel AM, Holstege FCP, Gray JC, Tytgat GAM, Scheijde-Vermeulen MA, Wijnen MHWA, Dierselhuis MP, Straathof K, Behjati S, Wu W, Heck AJR, Koster J, Nierkens S, Janoueix-Lerosey I, de Krijger RR, Baryawno N, Chesler L, Anderson J, Caron HN, Margaritis T, van Noesel MM, Molenaar JJ. Wienke J, et al. Among authors: nierkens s. Cancer Cell. 2024 Feb 12;42(2):283-300.e8. doi: 10.1016/j.ccell.2023.12.008. Epub 2024 Jan 4. Cancer Cell. 2024. PMID: 38181797 Free PMC article.
Combining CRISPR-Cas9 and TCR exchange to generate a safe and efficient cord blood-derived T cell product for pediatric relapsed AML.
Lo Presti V, Meringa A, Dunnebach E, van Velzen A, Moreira AV, Stam RW, Kotecha RS, Krippner-Heidenreich A, Heidenreich OT, Plantinga M, Cornel A, Sebestyen Z, Kuball J, van Til NP, Nierkens S. Lo Presti V, et al. Among authors: nierkens s. J Immunother Cancer. 2024 Apr 5;12(4):e008174. doi: 10.1136/jitc-2023-008174. J Immunother Cancer. 2024. PMID: 38580329 Free PMC article.
BEHAV3D: a 3D live imaging platform for comprehensive analysis of engineered T cell behavior and tumor response.
Alieva M, Barrera Román M, de Blank S, Petcu D, Zeeman AL, Dautzenberg NMM, Cornel AM, van de Ven C, Pieters R, den Boer ML, Nierkens S, Calkoen FGJ, Clevers H, Kuball J, Sebestyén Z, Wehrens EJ, Dekkers JF, Rios AC. Alieva M, et al. Among authors: nierkens s. Nat Protoc. 2024 Mar 19. doi: 10.1038/s41596-024-00972-6. Online ahead of print. Nat Protoc. 2024. PMID: 38504137 Review.
Targeting pediatric cancers via T-cell recognition of the monomorphic MHC class I-related protein MR1.
Cornel AM, van der Sman L, van Dinter JT, Arrabito M, Dunnebach E, van Hoesel M, Kluiver TA, Lopes AP, Dautzenberg NMM, Dekker L, van Rijn JM, van den Beemt DAMH, Buhl JL, du Chatinier A, Barneh F, Lu Y, Lo Nigro L, Krippner-Heidenreich A, Sebestyén Z, Kuball J, Hulleman E, Drost J, van Heesch S, Heidenreich OT, Peng WC, Nierkens S. Cornel AM, et al. Among authors: nierkens s. J Immunother Cancer. 2024 Mar 21;12(3):e007538. doi: 10.1136/jitc-2023-007538. J Immunother Cancer. 2024. PMID: 38519054 Free PMC article.
Highly multiplexed spatial analysis identifies tissue-resident memory T cells as drivers of ulcerative and immune checkpoint inhibitor colitis.
van Eijs MJM, Ter Linde JJM, Baars MJD, Amini M, Laclé MM, Brand EC, Delemarre EM, Drylewicz J, Nierkens S, Verheijden RJ, Oldenburg B, Vercoulen Y, Suijkerbuijk KPM, van Wijk F. van Eijs MJM, et al. Among authors: nierkens s. iScience. 2023 Sep 11;26(10):107891. doi: 10.1016/j.isci.2023.107891. eCollection 2023 Oct 20. iScience. 2023. PMID: 37766980 Free PMC article.
Risk Factors for Immune Checkpoint Inhibitor-Mediated Cardiovascular Toxicities.
Yousif LI, Screever EM, Versluis D, Aboumsallem JP, Nierkens S, Manintveld OC, de Boer RA, Meijers WC. Yousif LI, et al. Among authors: nierkens s. Curr Oncol Rep. 2023 Jul;25(7):753-763. doi: 10.1007/s11912-023-01414-4. Epub 2023 Apr 20. Curr Oncol Rep. 2023. PMID: 37079251 Free PMC article. Review.
Co-cultures of colon cancer cells and cancer-associated fibroblasts recapitulate the aggressive features of mesenchymal-like colon cancer.
Strating E, Verhagen MP, Wensink E, Dünnebach E, Wijler L, Aranguren I, De la Cruz AS, Peters NA, Hageman JH, van der Net MMC, van Schelven S, Laoukili J, Fodde R, Roodhart J, Nierkens S, Snippert H, Gloerich M, Rinkes IB, Elias SG, Kranenburg O. Strating E, et al. Among authors: nierkens s. Front Immunol. 2023 May 16;14:1053920. doi: 10.3389/fimmu.2023.1053920. eCollection 2023. Front Immunol. 2023. PMID: 37261365 Free PMC article.
A multidimensional analysis reveals distinct immune phenotypes and tertiary lymphoid structure-like aggregates in the bone marrow of pediatric acute myeloid leukemia.
Koedijk JB, van der Werf I, Penter L, Vermeulen MA, Barneh F, Perzolli A, Meesters-Ensing JI, Fiocco M, de Groot-Kruseman HA, Moeniralam R, Christensen KB, Porter B, Pfaff K, Garcia JS, Rodig SJ, Wu CJ, Hasle H, Nierkens S, Belderbos ME, Zwaan CM, Heidenreich O. Koedijk JB, et al. Among authors: nierkens s. medRxiv [Preprint]. 2023 Oct 30:2023.03.03.23286485. doi: 10.1101/2023.03.03.23286485. medRxiv. 2023. PMID: 37961528 Free PMC article. Preprint.
202 results