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Cortical Layer Inversion and Deregulation of Reelin Signaling in the Absence of SOCS6 and SOCS7.
Lawrenson ID, Krebs DL, Linossi EM, Zhang JG, McLennan TJ, Collin C, McRae HM, Kolesnik TB, Koh K, Britto JM, Kueh AJ, Sheikh BN, El-Saafin F, Nicola NA, Tan SS, Babon JJ, Nicholson SE, Alexander WS, Thomas T, Voss AK. Lawrenson ID, et al. Among authors: nicholson se. Cereb Cortex. 2017 Jan 1;27(1):576-588. doi: 10.1093/cercor/bhv253. Cereb Cortex. 2017. PMID: 26503265
Twenty proteins containing a C-terminal SOCS box form five structural classes.
Hilton DJ, Richardson RT, Alexander WS, Viney EM, Willson TA, Sprigg NS, Starr R, Nicholson SE, Metcalf D, Nicola NA. Hilton DJ, et al. Among authors: nicholson se. Proc Natl Acad Sci U S A. 1998 Jan 6;95(1):114-9. doi: 10.1073/pnas.95.1.114. Proc Natl Acad Sci U S A. 1998. PMID: 9419338 Free PMC article.
The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation.
Zhang JG, Farley A, Nicholson SE, Willson TA, Zugaro LM, Simpson RJ, Moritz RL, Cary D, Richardson R, Hausmann G, Kile BT, Kent SB, Alexander WS, Metcalf D, Hilton DJ, Nicola NA, Baca M. Zhang JG, et al. Among authors: nicholson se. Proc Natl Acad Sci U S A. 1999 Mar 2;96(5):2071-6. doi: 10.1073/pnas.96.5.2071. Proc Natl Acad Sci U S A. 1999. PMID: 10051596 Free PMC article.
Suppressors of cytokine signaling (SOCS): negative regulators of signal transduction.
Alexander WS, Starr R, Metcalf D, Nicholson SE, Farley A, Elefanty AG, Brysha M, Kile BT, Richardson R, Baca M, Zhang JG, Willson TA, Viney EM, Sprigg NS, Rakar S, Corbin J, Mifsud S, DiRago L, Cary D, Nicola NA, Hilton DJ. Alexander WS, et al. Among authors: nicholson se. J Leukoc Biol. 1999 Oct;66(4):588-92. doi: 10.1002/jlb.66.4.588. J Leukoc Biol. 1999. PMID: 10534114 Review.
Negative regulation of cytokine signaling by the SOCS proteins.
Nicola NA, Nicholson SE, Metcalf D, Zhang JG, Baca M, Farley A, Willson TA, Starr R, Alexander W, Hilton DJ. Nicola NA, et al. Among authors: nicholson se. Cold Spring Harb Symp Quant Biol. 1999;64:397-404. doi: 10.1101/sqb.1999.64.397. Cold Spring Harb Symp Quant Biol. 1999. PMID: 11232314 Review. No abstract available.
SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation.
Krebs DL, Uren RT, Metcalf D, Rakar S, Zhang JG, Starr R, De Souza DP, Hanzinikolas K, Eyles J, Connolly LM, Simpson RJ, Nicola NA, Nicholson SE, Baca M, Hilton DJ, Alexander WS. Krebs DL, et al. Among authors: nicholson se. Mol Cell Biol. 2002 Jul;22(13):4567-78. doi: 10.1128/MCB.22.13.4567-4578.2002. Mol Cell Biol. 2002. PMID: 12052866 Free PMC article.
143 results