Nicholas RA - Search Results

1

Preclinical safety and efficacy characterization of an LpxC inhibitor against Gram-negative pathogens.

Zhao J, Cochrane CS, Najeeb J, Gooden D, Sciandra C, Fan P, Lemaitre N, Newns K, Nicholas RA, Guan Z, Thaden JT, Fowler VG Jr, Spasojevic I, Sebbane F, Toone EJ, Duncan C, Gammans R, Zhou P. Zhao J, et al. Among authors: nicholas ra. Sci Transl Med. 2023 Aug 9;15(708):eadf5668. doi: 10.1126/scitranslmed.adf5668. Epub 2023 Aug 9. Sci Transl Med. 2023. PMID: 37556556

2

Species-specific and inhibitor-dependent conformations of LpxC: implications for antibiotic design.

Lee CJ, Liang X, Chen X, Zeng D, Joo SH, Chung HS, Barb AW, Swanson SM, Nicholas RA, Li Y, Toone EJ, Raetz CR, Zhou P. Lee CJ, et al. Among authors: nicholas ra. Chem Biol. 2011 Jan 28;18(1):38-47. doi: 10.1016/j.chembiol.2010.11.011. Epub 2010 Dec 16. Chem Biol. 2011. PMID: 21167751 Free PMC article.

3

Antimicrobial Resistance in Neisseria gonorrhoeae: Proceedings of the STAR Sexually Transmitted Infection-Clinical Trial Group Programmatic Meeting.

Cristillo AD, Bristow CC, Torrone E, Dillon JA, Kirkcaldy RD, Dong H, Grad YH, Nicholas RA, Rice PA, Lawrence K, Oldach D, Shafer WM, Zhou P, Wi TE, Morris SR, Klausner JD. Cristillo AD, et al. Among authors: nicholas ra. Sex Transm Dis. 2019 Mar;46(3):e18-e25. doi: 10.1097/OLQ.0000000000000929. Sex Transm Dis. 2019. PMID: 30363025 Free PMC article. Clinical Trial.

4

Mutations in PBP2 from ceftriaxone-resistant Neisseria gonorrhoeae alter the dynamics of the β3-β4 loop to favor a low-affinity drug-binding state.

Fenton BA, Tomberg J, Sciandra CA, Nicholas RA, Davies C, Zhou P. Fenton BA, et al. Among authors: nicholas ra. J Biol Chem. 2021 Oct;297(4):101188. doi: 10.1016/j.jbc.2021.101188. Epub 2021 Sep 13. J Biol Chem. 2021. PMID: 34529975 Free PMC article.

5

Commentary on 'Identification and characterization of select oxysterols as ligands for GPR17'.

Nicholas RA. Nicholas RA. Br J Pharmacol. 2023 Apr;180(8):1186-1187. doi: 10.1111/bph.16026. Epub 2023 Jan 20. Br J Pharmacol. 2023. PMID: 36669769 Free article. No abstract available.

6

Commensal Neisseria species share immune suppressive mechanisms with Neisseria gonorrhoeae.

Zhu W, Cardenas-Alvarez MX, Tomberg J, Little MB, Duncan JA, Nicholas RA. Zhu W, et al. Among authors: nicholas ra. PLoS One. 2023 Apr 7;18(4):e0284062. doi: 10.1371/journal.pone.0284062. eCollection 2023. PLoS One. 2023. PMID: 37027389 Free PMC article.

7

Ureidopenicillins Are Potent Inhibitors of Penicillin-Binding Protein 2 from Multidrug-Resistant Neisseria gonorrhoeae H041.

Turner JM, Stratton CM, Bala S, Cardenas Alvarez M, Nicholas RA, Davies C. Turner JM, et al. Among authors: nicholas ra. ACS Infect Dis. 2024 Apr 12;10(4):1298-1311. doi: 10.1021/acsinfecdis.3c00713. Epub 2024 Mar 6. ACS Infect Dis. 2024. PMID: 38446051

8

Charged residues in the C-terminus of the P2Y1 receptor constitute a basolateral-sorting signal.

Wolff SC, Qi AD, Harden TK, Nicholas RA. Wolff SC, et al. Among authors: nicholas ra. J Cell Sci. 2010 Jul 15;123(Pt 14):2512-20. doi: 10.1242/jcs.060723. J Cell Sci. 2010. PMID: 20592187 Free PMC article.

9

Diffusion of antibiotics through the PilQ secretin in Neisseria gonorrhoeae occurs through the immature, sodium dodecyl sulfate-labile form.

Nandi S, Swanson S, Tomberg J, Nicholas RA. Nandi S, et al. Among authors: nicholas ra. J Bacteriol. 2015 Apr;197(8):1308-21. doi: 10.1128/JB.02628-14. Epub 2015 Jan 20. J Bacteriol. 2015. PMID: 25605303 Free PMC article.

10

Insights into platelet P2Y12 receptor activation.

Nicholas RA. Nicholas RA. Blood. 2015 Feb 5;125(6):893-5. doi: 10.1182/blood-2014-12-615336. Blood. 2015. PMID: 25655454 Free article. No abstract available.

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