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Pharmacological inhibition of TBK1/IKKε blunts immunopathology in a murine model of SARS-CoV-2 infection.
Ullah TR, Johansen MD, Balka KR, Ambrose RL, Gearing LJ, Roest J, Vivian JP, Sapkota S, Jayasekara WSN, Wenholz DS, Aldilla VR, Zeng J, Miemczyk S, Nguyen DH, Hansbro NG, Venkatraman R, Kang JH, Pang ES, Thomas BJ, Alharbi AS, Rezwan R, O'Keeffe M, Donald WA, Ellyard JI, Wong W, Kumar N, Kile BT, Vinuesa CG, Kelly GE, Laczka OF, Hansbro PM, De Nardo D, Gantier MP. Ullah TR, et al. Among authors: nguyen dh. Nat Commun. 2023 Sep 18;14(1):5666. doi: 10.1038/s41467-023-41381-9. Nat Commun. 2023. PMID: 37723181 Free PMC article.
Mucosal TLR2-activating protein-based vaccination induces potent pulmonary immunity and protection against SARS-CoV-2 in mice.
Ashhurst AS, Johansen MD, Maxwell JWC, Stockdale S, Ashley CL, Aggarwal A, Siddiquee R, Miemczyk S, Nguyen DH, Mackay JP, Counoupas C, Byrne SN, Turville S, Steain M, Triccas JA, Hansbro PM, Payne RJ, Britton WJ. Ashhurst AS, et al. Among authors: nguyen dh. Nat Commun. 2022 Nov 15;13(1):6972. doi: 10.1038/s41467-022-34297-3. Nat Commun. 2022. PMID: 36379950 Free PMC article.
Increased SARS-CoV-2 Infection, Protease, and Inflammatory Responses in Chronic Obstructive Pulmonary Disease Primary Bronchial Epithelial Cells Defined with Single-Cell RNA Sequencing.
Johansen MD, Mahbub RM, Idrees S, Nguyen DH, Miemczyk S, Pathinayake P, Nichol K, Hansbro NG, Gearing LJ, Hertzog PJ, Gallego-Ortega D, Britton WJ, Saunders BM, Wark PA, Faiz A, Hansbro PM. Johansen MD, et al. Among authors: nguyen dh. Am J Respir Crit Care Med. 2022 Sep 15;206(6):712-729. doi: 10.1164/rccm.202108-1901OC. Am J Respir Crit Care Med. 2022. PMID: 35549656 Free PMC article.
Mucosal immunization with a delta-inulin adjuvanted recombinant spike vaccine elicits lung-resident immune memory and protects mice against SARS-CoV-2.
Stewart EL, Counoupas C, Johansen MD, Nguyen DH, Miemczyk S, Hansbro NG, Ferrell KC, Ashhurst A, Alca S, Ashley C, Steain M, Britton WJ, Hansbro PM, Petrovsky N, Triccas JA. Stewart EL, et al. Among authors: nguyen dh. Mucosal Immunol. 2022 Jun;15(6):1405-1415. doi: 10.1038/s41385-022-00578-9. Epub 2022 Nov 21. Mucosal Immunol. 2022. PMID: 36411332 Free PMC article.
A single dose, BCG-adjuvanted COVID-19 vaccine provides sterilising immunity against SARS-CoV-2 infection.
Counoupas C, Johansen MD, Stella AO, Nguyen DH, Ferguson AL, Aggarwal A, Bhattacharyya ND, Grey A, Hutchings O, Patel K, Siddiquee R, Stewart EL, Feng CG, Hansbro NG, Palendira U, Steain MC, Saunders BM, Low JKK, Mackay JP, Kelleher AD, Britton WJ, Turville SG, Hansbro PM, Triccas JA. Counoupas C, et al. Among authors: nguyen dh. NPJ Vaccines. 2021 Nov 30;6(1):143. doi: 10.1038/s41541-021-00406-4. NPJ Vaccines. 2021. PMID: 34848711 Free PMC article.
IL-22 and its receptors are increased in human and experimental COPD and contribute to pathogenesis.
Starkey MR, Plank MW, Casolari P, Papi A, Pavlidis S, Guo Y, Cameron GJM, Haw TJ, Tam A, Obiedat M, Donovan C, Hansbro NG, Nguyen DH, Nair PM, Kim RY, Horvat JC, Kaiko GE, Durum SK, Wark PA, Sin DD, Caramori G, Adcock IM, Foster PS, Hansbro PM. Starkey MR, et al. Among authors: nguyen dh. Eur Respir J. 2019 Jul 18;54(1):1800174. doi: 10.1183/13993003.00174-2018. Print 2019 Jul. Eur Respir J. 2019. PMID: 31196943 Free PMC article.
Aim2 suppresses cigarette smoke-induced neutrophil recruitment, neutrophil caspase-1 activation and anti-Ly6G-mediated neutrophil depletion.
Donovan C, Kim RY, Galvao I, Jarnicki AG, Brown AC, Jones-Freeman B, Gomez HM, Wadhwa R, Hortle E, Jayaraman R, Khan H, Pickles S, Sahu P, Chimankar V, Tu X, Ali MK, Mayall JR, Nguyen DH, Budden KF, Kumar V, Schroder K, Robertson AA, Cooper MA, Wark PA, Oliver BG, Horvat JC, Hansbro PM. Donovan C, et al. Among authors: nguyen dh. Immunol Cell Biol. 2022 Apr;100(4):235-249. doi: 10.1111/imcb.12537. Epub 2022 Mar 21. Immunol Cell Biol. 2022. PMID: 35175629 Free PMC article.
Airway and parenchymal transcriptomics in a novel model of asthma and COPD overlap.
Tu X, Kim RY, Brown AC, de Jong E, Jones-Freeman B, Ali MK, Gomez HM, Budden KF, Starkey MR, Cameron GJM, Loering S, Nguyen DH, Nair PM, Haw TJ, Alemao CA, Faiz A, Tay HL, Wark PAB, Knight DA, Foster PS, Bosco A, Horvat JC, Hansbro PM, Donovan C. Tu X, et al. Among authors: nguyen dh. J Allergy Clin Immunol. 2022 Oct;150(4):817-829.e6. doi: 10.1016/j.jaci.2022.04.032. Epub 2022 May 25. J Allergy Clin Immunol. 2022. PMID: 35643377
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