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Structural Investigations on Novel Non-Nucleoside Inhibitors of Human Norovirus Polymerase.
Giancotti G, Nannetti G, Padalino G, Landini M, Santos-Ferreira N, Van Dycke J, Naccarato V, Patel U, Silvestri R, Neyts J, Gozalbo-Rovira R, Rodríguez-Díaz J, Rocha-Pereira J, Brancale A, Ferla S, Bassetto M. Giancotti G, et al. Among authors: neyts j. Viruses. 2022 Dec 27;15(1):74. doi: 10.3390/v15010074. Viruses. 2022. PMID: 36680114 Free PMC article.
The imidazopyrrolopyridine analogue AG110 is a novel, highly selective inhibitor of pestiviruses that targets the viral RNA-dependent RNA polymerase at a hot spot for inhibition of viral replication.
Paeshuyse J, Chezal JM, Froeyen M, Leyssen P, Dutartre H, Vrancken R, Canard B, Letellier C, Li T, Mittendorfer H, Koenen F, Kerkhofs P, De Clercq E, Herdewijn P, Puerstinger G, Gueiffier A, Chavignon O, Teulade JC, Neyts J. Paeshuyse J, et al. Among authors: neyts j. J Virol. 2007 Oct;81(20):11046-53. doi: 10.1128/JVI.00388-07. Epub 2007 Aug 8. J Virol. 2007. PMID: 17686854 Free PMC article.
Comparative in vitro anti-hepatitis C virus activities of a selected series of polymerase, protease, and helicase inhibitors.
Paeshuyse J, Vliegen I, Coelmont L, Leyssen P, Tabarrini O, Herdewijn P, Mittendorfer H, Easmon J, Cecchetti V, Bartenschlager R, Puerstinger G, Neyts J. Paeshuyse J, et al. Among authors: neyts j. Antimicrob Agents Chemother. 2008 Sep;52(9):3433-7. doi: 10.1128/AAC.01534-07. Epub 2008 Jul 14. Antimicrob Agents Chemother. 2008. PMID: 18625766 Free PMC article.
Discovery of a novel HCV helicase inhibitor by a de novo drug design approach.
Kandil S, Biondaro S, Vlachakis D, Cummins AC, Coluccia A, Berry C, Leyssen P, Neyts J, Brancale A. Kandil S, et al. Among authors: neyts j. Bioorg Med Chem Lett. 2009 Jun 1;19(11):2935-7. doi: 10.1016/j.bmcl.2009.04.074. Epub 2009 Apr 22. Bioorg Med Chem Lett. 2009. PMID: 19414257
Favipiravir (T-705) inhibits in vitro norovirus replication.
Rocha-Pereira J, Jochmans D, Dallmeier K, Leyssen P, Nascimento MS, Neyts J. Rocha-Pereira J, et al. Among authors: neyts j. Biochem Biophys Res Commun. 2012 Aug 10;424(4):777-80. doi: 10.1016/j.bbrc.2012.07.034. Epub 2012 Jul 15. Biochem Biophys Res Commun. 2012. PMID: 22809499
662 results