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An anti-HER2 biparatopic antibody that induces unique HER2 clustering and complement-dependent cytotoxicity.
Weisser NE, Sanches M, Escobar-Cabrera E, O'Toole J, Whalen E, Chan PWY, Wickman G, Abraham L, Choi K, Harbourne B, Samiotakis A, Rojas AH, Volkers G, Wong J, Atkinson CE, Baardsnes J, Worrall LJ, Browman D, Smith EE, Baichoo P, Cheng CW, Guedia J, Kang S, Mukhopadhyay A, Newhook L, Ohrn A, Raghunatha P, Zago-Schmitt M, Schrag JD, Smith J, Zwierzchowski P, Scurll JM, Fung V, Black S, Strynadka NCJ, Gold MR, Presta LG, Ng G, Dixit S. Weisser NE, et al. Among authors: newhook l. Nat Commun. 2023 Mar 13;14(1):1394. doi: 10.1038/s41467-023-37029-3. Nat Commun. 2023. PMID: 36914633 Free PMC article.
The chimeric TAC receptor co-opts the T cell receptor yielding robust anti-tumor activity without toxicity.
Helsen CW, Hammill JA, Lau VWC, Mwawasi KA, Afsahi A, Bezverbnaya K, Newhook L, Hayes DL, Aarts C, Bojovic B, Denisova GF, Kwiecien JM, Brain I, Derocher H, Milne K, Nelson BH, Bramson JL. Helsen CW, et al. Among authors: newhook l. Nat Commun. 2018 Aug 3;9(1):3049. doi: 10.1038/s41467-018-05395-y. Nat Commun. 2018. PMID: 30076299 Free PMC article.
Patient, Caregiver, and Clinician Participation in Prioritization of Research Questions in Pediatric Hospital Medicine.
Gill PJ, Bayliss A, Sozer A, Buchanan F, Breen-Reid K, De Castris-Garcia K, Green M, Quinlan M, Wong N, Frappier S, Cowan K, Chan C, Arafeh D, Anwar MR, Macarthur C, Parkin PC, Cohen E, Mahant S; Canadian Pediatric Inpatient Research Network (PIRN). Gill PJ, et al. JAMA Netw Open. 2022 Apr 1;5(4):e229085. doi: 10.1001/jamanetworkopen.2022.9085. JAMA Netw Open. 2022. PMID: 35471568 Free PMC article.
51 results