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Cryo-EM structures of amyloid-β 42 filaments from human brains.
Yang Y, Arseni D, Zhang W, Huang M, Lövestam S, Schweighauser M, Kotecha A, Murzin AG, Peak-Chew SY, Macdonald J, Lavenir I, Garringer HJ, Gelpi E, Newell KL, Kovacs GG, Vidal R, Ghetti B, Ryskeldi-Falcon B, Scheres SHW, Goedert M. Yang Y, et al. Among authors: newell kl. Science. 2022 Jan 14;375(6577):167-172. doi: 10.1126/science.abm7285. Epub 2022 Jan 13. Science. 2022. PMID: 35025654 Free PMC article.
Structure-based inhibitors halt prion-like seeding by Alzheimer's disease-and tauopathy-derived brain tissue samples.
Seidler PM, Boyer DR, Murray KA, Yang TP, Bentzel M, Sawaya MR, Rosenberg G, Cascio D, Williams CK, Newell KL, Ghetti B, DeTure MA, Dickson DW, Vinters HV, Eisenberg DS. Seidler PM, et al. Among authors: newell kl. J Biol Chem. 2019 Nov 1;294(44):16451-16464. doi: 10.1074/jbc.RA119.009688. Epub 2019 Sep 19. J Biol Chem. 2019. PMID: 31537646 Free PMC article.
Novel tau filament fold in corticobasal degeneration.
Zhang W, Tarutani A, Newell KL, Murzin AG, Matsubara T, Falcon B, Vidal R, Garringer HJ, Shi Y, Ikeuchi T, Murayama S, Ghetti B, Hasegawa M, Goedert M, Scheres SHW. Zhang W, et al. Among authors: newell kl. Nature. 2020 Apr;580(7802):283-287. doi: 10.1038/s41586-020-2043-0. Epub 2020 Feb 12. Nature. 2020. PMID: 32050258 Free PMC article.
Crystal structure of a conformational antibody that binds tau oligomers and inhibits pathological seeding by extracts from donors with Alzheimer's disease.
Abskharon R, Seidler PM, Sawaya MR, Cascio D, Yang TP, Philipp S, Williams CK, Newell KL, Ghetti B, DeTure MA, Dickson DW, Vinters HV, Felgner PL, Nakajima R, Glabe CG, Eisenberg DS. Abskharon R, et al. Among authors: newell kl. J Biol Chem. 2020 Jul 31;295(31):10662-10676. doi: 10.1074/jbc.RA120.013638. Epub 2020 Jun 3. J Biol Chem. 2020. PMID: 32493775 Free PMC article.
Tau Protein and Frontotemporal Dementias.
Goedert M, Spillantini MG, Falcon B, Zhang W, Newell KL, Hasegawa M, Scheres SHW, Ghetti B. Goedert M, et al. Among authors: newell kl. Adv Exp Med Biol. 2021;1281:177-199. doi: 10.1007/978-3-030-51140-1_12. Adv Exp Med Biol. 2021. PMID: 33433876
Cryo-EM structures of tau filaments from Alzheimer's disease with PET ligand APN-1607.
Shi Y, Murzin AG, Falcon B, Epstein A, Machin J, Tempest P, Newell KL, Vidal R, Garringer HJ, Sahara N, Higuchi M, Ghetti B, Jang MK, Scheres SHW, Goedert M. Shi Y, et al. Among authors: newell kl. Acta Neuropathol. 2021 May;141(5):697-708. doi: 10.1007/s00401-021-02294-3. Epub 2021 Mar 16. Acta Neuropathol. 2021. PMID: 33723967 Free PMC article.
92 results