Newbatt YM - Search Results

1

The phosphoinositide-specific phospholipase C inhibitor U73122 (1-(6-((17beta-3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione) spontaneously forms conjugates with common components of cell culture medium.

Wilsher NE, Court WJ, Ruddle R, Newbatt YM, Aherne W, Sheldrake PW, Jones NP, Katan M, Eccles SA, Raynaud FI. Wilsher NE, et al. Among authors: newbatt ym. Drug Metab Dispos. 2007 Jul;35(7):1017-22. doi: 10.1124/dmd.106.014498. Epub 2007 Apr 2. Drug Metab Dispos. 2007. PMID: 17403917

2

High-throughput screening assay for identification of small molecule inhibitors of Aurora2/STK15 kinase.

Sun C, Newbatt Y, Douglas L, Workman P, Aherne W, Linardopoulos S. Sun C, et al. J Biomol Screen. 2004 Aug;9(5):391-7. doi: 10.1177/1087057104264071. J Biomol Screen. 2004. PMID: 15296638

3

Identification of small-molecule inhibitors of protein kinase B (PKB/AKT) in an AlphaScreenTM high-throughput screen.

Burns S, Travers J, Collins I, Rowlands MG, Newbatt Y, Thompson N, Garrett MD, Workman P, Aherne W. Burns S, et al. J Biomol Screen. 2006 Oct;11(7):822-7. doi: 10.1177/1087057106290992. Epub 2006 Aug 10. J Biomol Screen. 2006. PMID: 16902245

4

Structural and mechanistic aspects of phospholipase Cgamma regulation.

Katan M, Rodriguez R, Matsuda M, Newbatt YM, Aherne GW. Katan M, et al. Among authors: newbatt ym. Adv Enzyme Regul. 2003;43:77-85. doi: 10.1016/s0065-2571(02)00027-4. Adv Enzyme Regul. 2003. PMID: 12791384 Review. No abstract available.

5

Isothiazolones as inhibitors of PCAF and p300 histone acetyltransferase activity.

Stimson L, Rowlands MG, Newbatt YM, Smith NF, Raynaud FI, Rogers P, Bavetsias V, Gorsuch S, Jarman M, Bannister A, Kouzarides T, McDonald E, Workman P, Aherne GW. Stimson L, et al. Among authors: newbatt ym. Mol Cancer Ther. 2005 Oct;4(10):1521-32. doi: 10.1158/1535-7163.MCT-05-0135. Mol Cancer Ther. 2005. PMID: 16227401

6

High-throughput screening assay for inhibitors of heat-shock protein 90 ATPase activity.

Rowlands MG, Newbatt YM, Prodromou C, Pearl LH, Workman P, Aherne W. Rowlands MG, et al. Among authors: newbatt ym. Anal Biochem. 2004 Apr 15;327(2):176-83. doi: 10.1016/j.ab.2003.10.038. Anal Biochem. 2004. PMID: 15051534

7

Identification of inhibitors of the kinase activity of oncogenic V600E BRAF in an enzyme cascade high-throughput screen.

Newbatt Y, Burns S, Hayward R, Whittaker S, Kirk R, Marshall C, Springer C, McDonald E; Cancer Genome Project; Marais R, Workman P, Aherne W. Newbatt Y, et al. J Biomol Screen. 2006 Mar;11(2):145-54. doi: 10.1177/1087057105283584. Epub 2005 Dec 16. J Biomol Screen. 2006. PMID: 16361694

8

Identification by high-throughput screening of viridin analogs as biochemical and cell-based inhibitors of the cell cycle-regulated nek2 kinase.

Hayward DG, Newbatt Y, Pickard L, Byrne E, Mao G, Burns S, Sahota NK, Workman P, Collins I, Aherne W, Fry AM. Hayward DG, et al. J Biomol Screen. 2010 Sep;15(8):918-927. doi: 10.1177/1087057110376537. Epub 2010 Jul 27. J Biomol Screen. 2010. PMID: 20664067 Free PMC article.

9

Binding to an Unusual Inactive Kinase Conformation by Highly Selective Inhibitors of Inositol-Requiring Enzyme 1α Kinase-Endoribonuclease.

Colombano G, Caldwell JJ, Matthews TP, Bhatia C, Joshi A, McHardy T, Mok NY, Newbatt Y, Pickard L, Strover J, Hedayat S, Walton MI, Myers SM, Jones AM, Saville H, McAndrew C, Burke R, Eccles SA, Davies FE, Bayliss R, Collins I. Colombano G, et al. J Med Chem. 2019 Mar 14;62(5):2447-2465. doi: 10.1021/acs.jmedchem.8b01721. Epub 2019 Mar 5. J Med Chem. 2019. PMID: 30779566 Free PMC article.

10

Identification of autophosphorylation inhibitors of the inositol-requiring enzyme 1 alpha (IRE1α) by high-throughput screening using a DELFIA assay.

Newbatt Y, Hardcastle A, McAndrew PC, Strover JA, Mirza A, Morgan GJ, Burke R, Davies FE, Collins I, van Montfort RL. Newbatt Y, et al. J Biomol Screen. 2013 Mar;18(3):298-308. doi: 10.1177/1087057112465647. Epub 2012 Nov 8. J Biomol Screen. 2013. PMID: 23139381

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