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Norbornane-based nucleoside and nucleotide analogues locked in North conformation.
Dejmek M, Šála M, Hřebabecký H, Dračínský M, Procházková E, Chalupská D, Klíma M, Plačková P, Hájek M, Andrei G, Naesens L, Leyssen P, Neyts J, Balzarini J, Boura E, Nencka R. Dejmek M, et al. Among authors: nencka r. Bioorg Med Chem. 2015 Jan 1;23(1):184-91. doi: 10.1016/j.bmc.2014.11.011. Epub 2014 Nov 15. Bioorg Med Chem. 2015. PMID: 25435471
Nucleoside inhibitors of tick-borne encephalitis virus.
Eyer L, Valdés JJ, Gil VA, Nencka R, Hřebabecký H, Šála M, Salát J, Černý J, Palus M, De Clercq E, Růžek D. Eyer L, et al. Among authors: nencka r. Antimicrob Agents Chemother. 2015 Sep;59(9):5483-93. doi: 10.1128/AAC.00807-15. Epub 2015 Jun 29. Antimicrob Agents Chemother. 2015. PMID: 26124166 Free PMC article.
Nucleoside Inhibitors of Zika Virus.
Eyer L, Nencka R, Huvarová I, Palus M, Joao Alves M, Gould EA, De Clercq E, Růžek D. Eyer L, et al. Among authors: nencka r. J Infect Dis. 2016 Sep 1;214(5):707-11. doi: 10.1093/infdis/jiw226. Epub 2016 May 27. J Infect Dis. 2016. PMID: 27234417
Rational Design of Novel Highly Potent and Selective Phosphatidylinositol 4-Kinase IIIβ (PI4KB) Inhibitors as Broad-Spectrum Antiviral Agents and Tools for Chemical Biology.
Mejdrová I, Chalupská D, Plačková P, Müller C, Šála M, Klíma M, Baumlová A, Hřebabecký H, Procházková E, Dejmek M, Strunin D, Weber J, Lee G, Matoušová M, Mertlíková-Kaiserová H, Ziebuhr J, Birkus G, Boura E, Nencka R. Mejdrová I, et al. Among authors: nencka r. J Med Chem. 2017 Jan 12;60(1):100-118. doi: 10.1021/acs.jmedchem.6b01465. Epub 2016 Dec 22. J Med Chem. 2017. PMID: 28004945
Escape of Tick-Borne Flavivirus from 2'-C-Methylated Nucleoside Antivirals Is Mediated by a Single Conservative Mutation in NS5 That Has a Dramatic Effect on Viral Fitness.
Eyer L, Kondo H, Zouharova D, Hirano M, Valdés JJ, Muto M, Kastl T, Kobayashi S, Haviernik J, Igarashi M, Kariwa H, Vaculovicova M, Cerny J, Kizek R, Kröger A, Lienenklaus S, Dejmek M, Nencka R, Palus M, Salat J, De Clercq E, Yoshii K, Ruzek D. Eyer L, et al. Among authors: nencka r. J Virol. 2017 Oct 13;91(21):e01028-17. doi: 10.1128/JVI.01028-17. Print 2017 Nov 1. J Virol. 2017. PMID: 28814513 Free PMC article.
80 results