Navarro S - Search Results

1

Preclinical studies of efficacy thresholds and tolerability of a clinically ready lentiviral vector for pyruvate kinase deficiency treatment.

Navarro S, Quintana-Bustamante O, Sanchez-Dominguez R, Lopez-Manzaneda S, Ojeda-Perez I, Garcia-Torralba A, Alberquilla O, Law K, Beard BC, Bastone A, Rothe M, Villanueva M, Ramirez JC, Fañanas-Baquero S, Nieto-Romero V, Molinos-Vicente A, Gutierrez S, Nicoletti E, García-Bravo M, Bueren JA, Schwartz JD, Segovia JC. Navarro S, et al. Mol Ther Methods Clin Dev. 2021 Jul 29;22:350-359. doi: 10.1016/j.omtm.2021.07.006. eCollection 2021 Sep 10. Mol Ther Methods Clin Dev. 2021. PMID: 34514027 Free PMC article.

2

A simplified approach to improve the efficiency and safety of ex vivo hematopoietic gene therapy in fanconi anemia patients.

Jacome A, Navarro S, Casado JA, Rio P, Madero L, Estella J, Sevilla J, Badell I, Ortega JJ, Olivé T, Hanenberg H, Segovia JC, Bueren JA. Jacome A, et al. Among authors: navarro s. Hum Gene Ther. 2006 Feb;17(2):245-50. doi: 10.1089/hum.2006.17.245. Hum Gene Ther. 2006. PMID: 16454658

3

Hematopoietic dysfunction in a mouse model for Fanconi anemia group D1.

Navarro S, Meza NW, Quintana-Bustamante O, Casado JA, Jacome A, McAllister K, Puerto S, Surrallés J, Segovia JC, Bueren JA. Navarro S, et al. Mol Ther. 2006 Oct;14(4):525-35. doi: 10.1016/j.ymthe.2006.05.018. Epub 2006 Jul 20. Mol Ther. 2006. PMID: 16859999 Free article.

4

In vitro and in vivo expression of human erythrocyte pyruvate kinase in erythroid cells: a gene therapy approach.

Meza NW, Quintana-Bustamante O, Puyet A, Rio P, Navarro S, Diez A, Bueren JA, Bautista JM, Segovia JC. Meza NW, et al. Among authors: navarro s. Hum Gene Ther. 2007 Jun;18(6):502-14. doi: 10.1089/hum.2006.052. Hum Gene Ther. 2007. PMID: 17547515

5

In vivo proliferation advantage of genetically corrected hematopoietic stem cells in a mouse model of Fanconi anemia FA-D1.

Río P, Meza NW, González-Murillo A, Navarro S, Alvarez L, Surrallés J, Castella M, Guenechea G, Segovia JC, Hanenberg H, Bueren JA. Río P, et al. Among authors: navarro s. Blood. 2008 Dec 15;112(13):4853-61. doi: 10.1182/blood-2008-05-156356. Epub 2008 Sep 23. Blood. 2008. PMID: 18812474 Free article.

6

Lentiviral-mediated genetic correction of hematopoietic and mesenchymal progenitor cells from Fanconi anemia patients.

Jacome A, Navarro S, Río P, Yañez RM, González-Murillo A, Lozano ML, Lamana ML, Sevilla J, Olive T, Diaz-Heredia C, Badell I, Estella J, Madero L, Guenechea G, Casado J, Segovia JC, Bueren JA. Jacome A, et al. Among authors: navarro s. Mol Ther. 2009 Jun;17(6):1083-92. doi: 10.1038/mt.2009.26. Epub 2009 Mar 10. Mol Ther. 2009. PMID: 19277017 Free PMC article.

7

Insertional transformation of hematopoietic cells by self-inactivating lentiviral and gammaretroviral vectors.

Modlich U, Navarro S, Zychlinski D, Maetzig T, Knoess S, Brugman MH, Schambach A, Charrier S, Galy A, Thrasher AJ, Bueren J, Baum C. Modlich U, et al. Among authors: navarro s. Mol Ther. 2009 Nov;17(11):1919-28. doi: 10.1038/mt.2009.179. Epub 2009 Aug 11. Mol Ther. 2009. PMID: 19672245 Free PMC article.

8

Rescue of pyruvate kinase deficiency in mice by gene therapy using the human isoenzyme.

Meza NW, Alonso-Ferrero ME, Navarro S, Quintana-Bustamante O, Valeri A, Garcia-Gomez M, Bueren JA, Bautista JM, Segovia JC. Meza NW, et al. Among authors: navarro s. Mol Ther. 2009 Dec;17(12):2000-9. doi: 10.1038/mt.2009.200. Epub 2009 Sep 15. Mol Ther. 2009. PMID: 19755962 Free PMC article.

9

Development of lentiviral vectors with optimized transcriptional activity for the gene therapy of patients with Fanconi anemia.

González-Murillo A, Lozano ML, Alvarez L, Jacome A, Almarza E, Navarro S, Segovia JC, Hanenberg H, Guenechea G, Bueren JA, Río P. González-Murillo A, et al. Among authors: navarro s. Hum Gene Ther. 2010 May;21(5):623-30. doi: 10.1089/hum.2009.141. Hum Gene Ther. 2010. PMID: 20001454

10

Immunoresponse against the transgene limits hematopoietic engraftment of mice transplanted in utero with virally transduced fetal liver.

Alonso-Ferrero ME, Valeri A, Yañez R, Navarro S, Garin MI, Ramirez JC, Bueren JA, Segovia JC. Alonso-Ferrero ME, et al. Among authors: navarro s. Gene Ther. 2011 May;18(5):469-78. doi: 10.1038/gt.2010.160. Epub 2010 Dec 23. Gene Ther. 2011. PMID: 21179174

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