Navaratnam N - Search Results

1

A loss-of-function NUAK2 mutation in humans causes anencephaly due to impaired Hippo-YAP signaling.

Bonnard C, Navaratnam N, Ghosh K, Chan PW, Tan TT, Pomp O, Ng AYJ, Tohari S, Changede R, Carling D, Venkatesh B, Altunoglu U, Kayserili H, Reversade B. Bonnard C, et al. Among authors: navaratnam n. J Exp Med. 2020 Dec 7;217(12):e20191561. doi: 10.1084/jem.20191561. J Exp Med. 2020. PMID: 32845958 Free PMC article.

2

Effect of different γ-subunit isoforms on the regulation of AMPK.

Willows R, Navaratnam N, Lima A, Read J, Carling D. Willows R, et al. Among authors: navaratnam n. Biochem J. 2017 May 9;474(10):1741-1754. doi: 10.1042/BCJ20170046. Biochem J. 2017. PMID: 28302767 Free PMC article.

3

Mitochondria-derived ROS activate AMP-activated protein kinase (AMPK) indirectly.

Hinchy EC, Gruszczyk AV, Willows R, Navaratnam N, Hall AR, Bates G, Bright TP, Krieg T, Carling D, Murphy MP. Hinchy EC, et al. Among authors: navaratnam n. J Biol Chem. 2018 Nov 2;293(44):17208-17217. doi: 10.1074/jbc.RA118.002579. Epub 2018 Sep 19. J Biol Chem. 2018. PMID: 30232152 Free PMC article.

4

AMPK-independent down-regulation of cFLIP and sensitization to TRAIL-induced apoptosis by AMPK activators.

García-García C, Fumarola C, Navaratnam N, Carling D, López-Rivas A. García-García C, et al. Among authors: navaratnam n. Biochem Pharmacol. 2010 Mar 15;79(6):853-63. doi: 10.1016/j.bcp.2009.10.022. Epub 2009 Nov 5. Biochem Pharmacol. 2010. PMID: 19896469

5

Regulation of ploidy and senescence by the AMPK-related kinase NUAK1.

Humbert N, Navaratnam N, Augert A, Da Costa M, Martien S, Wang J, Martinez D, Abbadie C, Carling D, de Launoit Y, Gil J, Bernard D. Humbert N, et al. Among authors: navaratnam n. EMBO J. 2010 Jan 20;29(2):376-86. doi: 10.1038/emboj.2009.342. Epub 2009 Nov 19. EMBO J. 2010. PMID: 19927127 Free PMC article.

6

The novel choline kinase inhibitor ICL-CCIC-0019 reprograms cellular metabolism and inhibits cancer cell growth.

Trousil S, Kaliszczak M, Schug Z, Nguyen QD, Tomasi G, Favicchio R, Brickute D, Fortt R, Twyman FJ, Carroll L, Kalusa A, Navaratnam N, Adejumo T, Carling D, Gottlieb E, Aboagye EO. Trousil S, et al. Among authors: navaratnam n. Oncotarget. 2016 Jun 14;7(24):37103-37120. doi: 10.18632/oncotarget.9466. Oncotarget. 2016. PMID: 27206796 Free PMC article.

7

Potassium channel KCNA1 modulates oncogene-induced senescence and transformation.

Lallet-Daher H, Wiel C, Gitenay D, Navaratnam N, Augert A, Le Calvé B, Verbeke S, Carling D, Aubert S, Vindrieux D, Bernard D. Lallet-Daher H, et al. Among authors: navaratnam n. Cancer Res. 2013 Aug 15;73(16):5253-65. doi: 10.1158/0008-5472.CAN-12-3690. Epub 2013 Jun 17. Cancer Res. 2013. PMID: 23774215

8

Molecular modelling of the biosynthesis of the RNA-editing enzyme APOBEC-1, responsible for generating the alternative forms of apolipoprotein B.

Scott J, Navaratnam N, Carter C. Scott J, et al. Among authors: navaratnam n. Exp Physiol. 1999 Jul;84(4):791-800. Exp Physiol. 1999. PMID: 10481235

9

Arkadia enhances Nodal/TGF-beta signaling by coupling phospho-Smad2/3 activity and turnover.

Mavrakis KJ, Andrew RL, Lee KL, Petropoulou C, Dixon JE, Navaratnam N, Norris DP, Episkopou V. Mavrakis KJ, et al. Among authors: navaratnam n. PLoS Biol. 2007 Mar;5(3):e67. doi: 10.1371/journal.pbio.0050067. PLoS Biol. 2007. PMID: 17341133 Free PMC article.

10

The PLA2R1-JAK2 pathway upregulates ERRα and its mitochondrial program to exert tumor-suppressive action.

Griveau A, Devailly G, Eberst L, Navaratnam N, Le Calvé B, Ferrand M, Faull P, Augert A, Dante R, Vanacker JM, Vindrieux D, Bernard D. Griveau A, et al. Among authors: navaratnam n. Oncogene. 2016 Sep 22;35(38):5033-42. doi: 10.1038/onc.2016.43. Epub 2016 Apr 4. Oncogene. 2016. PMID: 27041564

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