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National Preclinical Sepsis Platform: developing a framework for accelerating innovation in Canadian sepsis research.
Mendelson AA, Lansdell C, Fox-Robichaud AE, Liaw P, Arora J, Cailhier JF, Cepinskas G, Charbonney E, Dos Santos C, Dwivedi D, Ellis CG, Fergusson D, Fiest K, Gill SE, Hendrick K, Hunniford VT, Kowalewska PM, Krewulak K, Lehmann C, Macala K, Marshall JC, Mawdsley L, McDonald B, McDonald E, Medeiros SK, Muniz VS, Osuchowski M, Presseau J, Sharma N, Sohrabipour S, Sunohara-Neilson J, Vázquez-Grande G, Veldhuizen RAW, Welsh D, Winston BW, Zarychanski R, Zhang H, Zhou J, Lalu MM; Sepsis Canada’s National Preclinical Sepsis Platform. Mendelson AA, et al. Intensive Care Med Exp. 2021 Mar 19;9(1):14. doi: 10.1186/s40635-020-00366-4. Intensive Care Med Exp. 2021. PMID: 33738642 Free PMC article.
Despite decades of preclinical research, no experimentally derived therapies for sepsis have been successfully adopted into routine clinical practice. ...To this end, we organized the first meeting of the National Preclinical Sepsis Platform …
Despite decades of preclinical research, no experimentally derived therapies for sepsis have been successfully adopted into ro …
Sex- and Gender-Dependent Differences in Clinical and Preclinical Sepsis.
Zhang MQ, Macala KF, Fox-Robichaud A, Mendelson AA, Lalu MM; Sepsis Canada National Preclinical Sepsis Platform. Zhang MQ, et al. Shock. 2021 Aug 1;56(2):178-187. doi: 10.1097/SHK.0000000000001717. Shock. 2021. PMID: 33399356 Review.
This may be of particular importance in sepsis, given the potential contribution of sex bias in the failures of translational sepsis research in adults and neonates. Clinical evidence of sex-dependent differences in sepsis is equivocal. Since clinical studies …
This may be of particular importance in sepsis, given the potential contribution of sex bias in the failures of translational seps …
Sepsis and obesity: a scoping review of diet-induced obesity murine models.
Eng M, Suthaaharan K, Newton L, Sheikh F, Fox-Robichaud A; National Preclinical Sepsis Platform, Sepsis Canada. Eng M, et al. Intensive Care Med Exp. 2024 Feb 23;12(1):15. doi: 10.1186/s40635-024-00603-0. Intensive Care Med Exp. 2024. PMID: 38388878 Free PMC article. Review.
BACKGROUND: Sepsis, the life-threatening host response to infection, is a major cause of mortality. Obesity increases vulnerability to sepsis; however, some degree of obesity may be protective, called the "obesity paradox". ...
BACKGROUND: Sepsis, the life-threatening host response to infection, is a major cause of mortality. Obesity increases vulnerability t …
Sex-based analysis of treatment responses in animal models of sepsis: a preclinical systematic review protocol.
Zhang M, Fergusson DA, Sharma R, Khoo C, Mendelson AA, McDonald B, Macala KF, Sharma N, Gill SE, Fiest KM, Lehmann C, Shorr R, Jahandideh F, Bourque SL, Liaw PC, Fox-Robichaud A, Lalu MM; Canadian Critical Care Translational Biology Group, the Sepsis Canada National Preclinical Sepsis Platform. Zhang M, et al. Syst Rev. 2023 Mar 21;12(1):50. doi: 10.1186/s13643-023-02189-2. Syst Rev. 2023. PMID: 36945012 Free PMC article.
We propose a systematic review to assess the impact of biological sex on baseline responses to disease induction as well as treatment responses in animal models of sepsis. Given the lack of guidance surrounding sex-based analyses in preclinical systematic reviews, c …
We propose a systematic review to assess the impact of biological sex on baseline responses to disease induction as well as treatment respon …
Development and characterization of a fecal-induced peritonitis model of murine sepsis: results from a multi-laboratory study and iterative modification of experimental conditions.
Sharma N, Chwastek D, Dwivedi DJ, Schlechte J, Yu IL, McDonald B, Arora J, Cani E, Eng M, Engelberts D, Kuhar E, Medeiros SK, Bourque SL, Cepinskas G, Gill SE, Jahandideh F, Macala KF, Panahi S, Pape C, Sontag D, Sunohara-Neilson J, Fergusson DA, Fox-Robichaud AE, Liaw PC, Lalu MM, Mendelson AA; National Preclinical Sepsis Platform, Sepsis Canada. Sharma N, et al. Intensive Care Med Exp. 2023 Jul 17;11(1):45. doi: 10.1186/s40635-023-00533-3. Intensive Care Med Exp. 2023. PMID: 37460911 Free PMC article.
BACKGROUND: Preclinical sepsis models have been criticized for their inability to recapitulate human sepsis and suffer from methodological shortcomings that limit external validity and reproducibility. The National Preclinical Sepsis P …
BACKGROUND: Preclinical sepsis models have been criticized for their inability to recapitulate human sepsis and suffer …