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323 results

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Page 1
Fluoxetine ameliorates mucopolysaccharidosis type IIIA.
Capuozzo A, Montefusco S, Cacace V, Sofia M, Esposito A, Napolitano G, Nusco E, Polishchuk E, Pizzo MT, De Risi M, De Leonibus E, Sorrentino NC, Medina DL. Capuozzo A, et al. Among authors: napolitano g. Mol Ther. 2022 Apr 6;30(4):1432-1450. doi: 10.1016/j.ymthe.2022.01.037. Epub 2022 Feb 2. Mol Ther. 2022. PMID: 35121108 Free PMC article.
mTOR-dependent phosphorylation controls TFEB nuclear export.
Napolitano G, Esposito A, Choi H, Matarese M, Benedetti V, Di Malta C, Monfregola J, Medina DL, Lippincott-Schwartz J, Ballabio A. Napolitano G, et al. Nat Commun. 2018 Aug 17;9(1):3312. doi: 10.1038/s41467-018-05862-6. Nat Commun. 2018. PMID: 30120233 Free PMC article.
TFEB-driven endocytosis coordinates MTORC1 signaling and autophagy.
Nnah IC, Wang B, Saqcena C, Weber GF, Bonder EM, Bagley D, De Cegli R, Napolitano G, Medina DL, Ballabio A, Dobrowolski R. Nnah IC, et al. Among authors: napolitano g. Autophagy. 2019 Jan;15(1):151-164. doi: 10.1080/15548627.2018.1511504. Epub 2018 Sep 10. Autophagy. 2019. PMID: 30145926 Free PMC article.
A substrate-specific mTORC1 pathway underlies Birt-Hogg-Dubé syndrome.
Napolitano G, Di Malta C, Esposito A, de Araujo MEG, Pece S, Bertalot G, Matarese M, Benedetti V, Zampelli A, Stasyk T, Siciliano D, Venuta A, Cesana M, Vilardo C, Nusco E, Monfregola J, Calcagnì A, Di Fiore PP, Huber LA, Ballabio A. Napolitano G, et al. Nature. 2020 Sep;585(7826):597-602. doi: 10.1038/s41586-020-2444-0. Epub 2020 Jul 1. Nature. 2020. PMID: 32612235 Free PMC article.
LC3 lipidation is essential for TFEB activation during the lysosomal damage response to kidney injury.
Nakamura S, Shigeyama S, Minami S, Shima T, Akayama S, Matsuda T, Esposito A, Napolitano G, Kuma A, Namba-Hamano T, Nakamura J, Yamamoto K, Sasai M, Tokumura A, Miyamoto M, Oe Y, Fujita T, Terawaki S, Takahashi A, Hamasaki M, Yamamoto M, Okada Y, Komatsu M, Nagai T, Takabatake Y, Xu H, Isaka Y, Ballabio A, Yoshimori T. Nakamura S, et al. Among authors: napolitano g. Nat Cell Biol. 2020 Oct;22(10):1252-1263. doi: 10.1038/s41556-020-00583-9. Epub 2020 Sep 28. Nat Cell Biol. 2020. PMID: 32989250
c-Abl Inhibition Activates TFEB and Promotes Cellular Clearance in a Lysosomal Disorder.
Contreras PS, Tapia PJ, González-Hódar L, Peluso I, Soldati C, Napolitano G, Matarese M, Heras ML, Valls C, Martinez A, Balboa E, Castro J, Leal N, Platt FM, Sobota A, Winter D, Klein AD, Medina DL, Ballabio A, Alvarez AR, Zanlungo S. Contreras PS, et al. Among authors: napolitano g. iScience. 2020 Oct 15;23(11):101691. doi: 10.1016/j.isci.2020.101691. eCollection 2020 Nov 20. iScience. 2020. PMID: 33163944 Free PMC article.
Repurposing of tamoxifen ameliorates CLN3 and CLN7 disease phenotype.
Soldati C, Lopez-Fabuel I, Wanderlingh LG, Garcia-Macia M, Monfregola J, Esposito A, Napolitano G, Guevara-Ferrer M, Scotto Rosato A, Krogsaeter EK, Paquet D, Grimm CM, Montefusco S, Braulke T, Storch S, Mole SE, De Matteis MA, Ballabio A, Sampaio JL, McKay T, Johannes L, Bolaños JP, Medina DL. Soldati C, et al. Among authors: napolitano g. EMBO Mol Med. 2021 Oct 7;13(10):e13742. doi: 10.15252/emmm.202013742. Epub 2021 Aug 19. EMBO Mol Med. 2021. PMID: 34411438 Free PMC article.
Current methods to analyze lysosome morphology, positioning, motility and function.
Barral DC, Staiano L, Guimas Almeida C, Cutler DF, Eden ER, Futter CE, Galione A, Marques ARA, Medina DL, Napolitano G, Settembre C, Vieira OV, Aerts JMFG, Atakpa-Adaji P, Bruno G, Capuozzo A, De Leonibus E, Di Malta C, Escrevente C, Esposito A, Grumati P, Hall MJ, Teodoro RO, Lopes SS, Luzio JP, Monfregola J, Montefusco S, Platt FM, Polishchuck R, De Risi M, Sambri I, Soldati C, Seabra MC. Barral DC, et al. Among authors: napolitano g. Traffic. 2022 May;23(5):238-269. doi: 10.1111/tra.12839. Epub 2022 Apr 24. Traffic. 2022. PMID: 35343629 Free PMC article. Review.
Structure of the lysosomal mTORC1-TFEB-Rag-Ragulator megacomplex.
Cui Z, Napolitano G, de Araujo MEG, Esposito A, Monfregola J, Huber LA, Ballabio A, Hurley JH. Cui Z, et al. Among authors: napolitano g. Nature. 2023 Feb;614(7948):572-579. doi: 10.1038/s41586-022-05652-7. Epub 2023 Jan 25. Nature. 2023. PMID: 36697823 Free PMC article.
323 results