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Tyk2 is essential for IFN-alpha-induced gene expression in mast cells.
Mori Y, Hirose K, Suzuki K, Nakajima H, Seto Y, Ikeda K, Shimoda K, Nakayama K, Saito Y, Iwamoto I. Mori Y, et al. Among authors: nakayama k. Int Arch Allergy Immunol. 2004 Jun;134 Suppl 1:25-9. doi: 10.1159/000077789. Int Arch Allergy Immunol. 2004. PMID: 15166480
Partial impairment of interleukin-12 (IL-12) and IL-18 signaling in Tyk2-deficient mice.
Shimoda K, Tsutsui H, Aoki K, Kato K, Matsuda T, Numata A, Takase K, Yamamoto T, Nukina H, Hoshino T, Asano Y, Gondo H, Okamura T, Okamura S, Nakayama K, Nakanishi K, Niho Y, Harada M. Shimoda K, et al. Among authors: nakayama k. Blood. 2002 Mar 15;99(6):2094-9. doi: 10.1182/blood.v99.6.2094. Blood. 2002. PMID: 11877284 Free article.
Cutting edge: tyk2 is required for the induction and nuclear translocation of Daxx which regulates IFN-alpha-induced suppression of B lymphocyte formation.
Shimoda K, Kamesaki K, Numata A, Aoki K, Matsuda T, Oritani K, Tamiya S, Kato K, Takase K, Imamura R, Yamamoto T, Miyamoto T, Nagafuji K, Gondo H, Nagafuchi S, Nakayama K, Harada M. Shimoda K, et al. Among authors: nakayama k. J Immunol. 2002 Nov 1;169(9):4707-11. doi: 10.4049/jimmunol.169.9.4707. J Immunol. 2002. PMID: 12391177
Limitin, an interferon-like cytokine, transduces inhibitory signals on B-cell growth through activation of Tyk2, but not Stat1, followed by induction and nuclear translocation of Daxx.
Aoki K, Shimoda K, Oritani K, Matsuda T, Kamezaki K, Muromoto R, Numata A, Tamiya S, Haro T, Ishikawa F, Takase K, Yamamoto T, Yumioka T, Miyamoto T, Nagafuji K, Gondo H, Nagafuchi S, Nakayama K, Harada M. Aoki K, et al. Among authors: nakayama k. Exp Hematol. 2003 Dec;31(12):1317-22. doi: 10.1016/j.exphem.2003.08.011. Exp Hematol. 2003. PMID: 14662340 Free article.
3,772 results