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Phase separation of FSP1 promotes ferroptosis.
Nakamura T, Hipp C, Santos Dias Mourão A, Borggräfe J, Aldrovandi M, Henkelmann B, Wanninger J, Mishima E, Lytton E, Emler D, Proneth B, Sattler M, Conrad M. Nakamura T, et al. Nature. 2023 Jul;619(7969):371-377. doi: 10.1038/s41586-023-06255-6. Epub 2023 Jun 28. Nature. 2023. PMID: 37380771 Free PMC article.
A non-canonical vitamin K cycle is a potent ferroptosis suppressor.
Mishima E, Ito J, Wu Z, Nakamura T, Wahida A, Doll S, Tonnus W, Nepachalovich P, Eggenhofer E, Aldrovandi M, Henkelmann B, Yamada KI, Wanninger J, Zilka O, Sato E, Feederle R, Hass D, Maida A, Mourão ASD, Linkermann A, Geissler EK, Nakagawa K, Abe T, Fedorova M, Proneth B, Pratt DA, Conrad M. Mishima E, et al. Among authors: nakamura t. Nature. 2022 Aug;608(7924):778-783. doi: 10.1038/s41586-022-05022-3. Epub 2022 Aug 3. Nature. 2022. PMID: 35922516 Free PMC article.
DHODH inhibitors sensitize to ferroptosis by FSP1 inhibition.
Mishima E, Nakamura T, Zheng J, Zhang W, Mourão ASD, Sennhenn P, Conrad M. Mishima E, et al. Among authors: nakamura t. Nature. 2023 Jul;619(7968):E9-E18. doi: 10.1038/s41586-023-06269-0. Epub 2023 Jul 5. Nature. 2023. PMID: 37407687 No abstract available.
Integrated chemical and genetic screens unveil FSP1 mechanisms of ferroptosis regulation.
Nakamura T, Mishima E, Yamada N, Mourão ASD, Trümbach D, Doll S, Wanninger J, Lytton E, Sennhenn P, Nishida Xavier da Silva T, Angeli JPF, Sattler M, Proneth B, Conrad M. Nakamura T, et al. Nat Struct Mol Biol. 2023 Nov;30(11):1806-1815. doi: 10.1038/s41594-023-01136-y. Epub 2023 Nov 13. Nat Struct Mol Biol. 2023. PMID: 37957306 Free PMC article.
A tangible method to assess native ferroptosis suppressor activity.
Nakamura T, Ito J, Mourão ASD, Wahida A, Nakagawa K, Mishima E, Conrad M. Nakamura T, et al. Cell Rep Methods. 2024 Mar 25;4(3):100710. doi: 10.1016/j.crmeth.2024.100710. Epub 2024 Feb 24. Cell Rep Methods. 2024. PMID: 38401540 Free PMC article.
Inhibition of 7-dehydrocholesterol reductase prevents hepatic ferroptosis under an active state of sterol synthesis.
Yamada N, Karasawa T, Ito J, Yamamuro D, Morimoto K, Nakamura T, Komada T, Baatarjav C, Saimoto Y, Jinnouchi Y, Watanabe K, Miura K, Yahagi N, Nakagawa K, Matsumura T, Yamada KI, Ishibashi S, Sata N, Conrad M, Takahashi M. Yamada N, et al. Among authors: nakamura t. Nat Commun. 2024 Mar 12;15(1):2195. doi: 10.1038/s41467-024-46386-6. Nat Commun. 2024. PMID: 38472233 Free PMC article.
Hepatic arterial infusion of autologous CD34+ cells for hepatitis C virus-related decompensated cirrhosis: A multicenter, open-label, exploratory randomized controlled trial.
Nakamura T, Masuda A, Kako M, Enomoto H, Kaibori M, Fujita Y, Tanizawa K, Ioji T, Fujimori Y, Fukami K, Hazama T, Iwamoto H, Kako Y, Kobayashi K, Koga H, Nagafuji K, Ohtake T, Suzuki H, Takashima T, Tsukiyama T, Uojima H, Yamahara K, Yamakado K, Yamamoto H, Yoh K, Yoshihara S, Kawamoto A, Nishiguchi S, Kobayashi S, Torimura T, Kawaguchi T. Nakamura T, et al. Regen Ther. 2024 May 4;27:455-463. doi: 10.1016/j.reth.2024.04.018. eCollection 2024 Dec. Regen Ther. 2024. PMID: 38737403 Free PMC article.
Exploratory investigation of virtual lesions in gastrointestinal endoscopy using a novel phase-shift method for three-dimensional shape measurement.
Sakamoto T, Oda I, Okamura T, Cho H, Toyoshima N, Nonaka S, Suzuki H, Nakamura T, Watanabe D, Matsuo K, Hanano K, Takeyama T, Yoshinaga S, Saito Y. Sakamoto T, et al. Among authors: nakamura t. DEN Open. 2024 May 8;5(1):e381. doi: 10.1002/deo2.381. eCollection 2025 Apr. DEN Open. 2024. PMID: 38725875 Free PMC article.
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