Nakamura M - Search Results

1

Plasma concentrations of melengestrol acetate in humans extrapolated from the pharmacokinetics established in in vivo experiments with rats and chimeric mice with humanized liver and physiologically based pharmacokinetic modeling.

Tsukada A, Suemizu H, Murayama N, Takano R, Shimizu M, Nakamura M, Yamazaki H. Tsukada A, et al. Among authors: nakamura m. Regul Toxicol Pharmacol. 2013 Apr;65(3):316-24. doi: 10.1016/j.yrtph.2013.01.008. Epub 2013 Feb 5. Regul Toxicol Pharmacol. 2013. PMID: 23395687

2

In vivo formation of a glutathione conjugate derived from thalidomide in humanized uPA-NOG mice.

Yamazaki H, Suemizu H, Igaya S, Shimizu M, Shibata N, Nakamura M, Chowdhury G, Guengerich FP. Yamazaki H, et al. Among authors: nakamura m. Chem Res Toxicol. 2011 Mar 21;24(3):287-9. doi: 10.1021/tx200005g. Epub 2011 Feb 7. Chem Res Toxicol. 2011. PMID: 21299192 Free PMC article.

3

In vivo formation of dihydroxylated and glutathione conjugate metabolites derived from thalidomide and 5-Hydroxythalidomide in humanized TK-NOG mice.

Yamazaki H, Suemizu H, Shimizu M, Igaya S, Shibata N, Nakamura M, Chowdhury G, Guengerich FP. Yamazaki H, et al. Among authors: nakamura m. Chem Res Toxicol. 2012 Feb 20;25(2):274-6. doi: 10.1021/tx300009j. Epub 2012 Jan 25. Chem Res Toxicol. 2012. PMID: 22268628 Free PMC article.

4

In vivo drug interactions of the teratogen thalidomide with midazolam: heterotropic cooperativity of human cytochrome P450 in humanized TK-NOG mice.

Yamazaki H, Suemizu H, Murayama N, Utoh M, Shibata N, Nakamura M, Guengerich FP. Yamazaki H, et al. Among authors: nakamura m. Chem Res Toxicol. 2013 Mar 18;26(3):486-9. doi: 10.1021/tx400008g. Epub 2013 Mar 1. Chem Res Toxicol. 2013. PMID: 23419139 Free PMC article.

5

Chimeric mice with humanized liver as a model for testing organophosphate and carbamate pesticide exposure.

Suemizu H, Kawai K, Murayama N, Nakamura M, Yamazaki H. Suemizu H, et al. Among authors: nakamura m. Pest Manag Sci. 2018 Jun;74(6):1424-1430. doi: 10.1002/ps.4825. Epub 2018 Feb 22. Pest Manag Sci. 2018. PMID: 29235720 Free PMC article.

6

The human hepatic cell line HepaRG as a possible cell source for the generation of humanized liver TK-NOG mice.

Higuchi Y, Kawai K, Yamazaki H, Nakamura M, Bree F, Guguen-Guillouzo C, Suemizu H. Higuchi Y, et al. Among authors: nakamura m. Xenobiotica. 2014 Jan;44(2):146-53. doi: 10.3109/00498254.2013.836257. Epub 2013 Sep 25. Xenobiotica. 2014. PMID: 24066694 Free PMC article.

7

Thalidomide increases human hepatic cytochrome P450 3A enzymes by direct activation of the pregnane X receptor.

Murayama N, van Beuningen R, Suemizu H, Guillouzo CG, Shibata N, Yajima K, Utoh M, Shimizu M, Chesné C, Nakamura M, Guengerich FP, Houtman R, Yamazaki H. Murayama N, et al. Among authors: nakamura m. Chem Res Toxicol. 2014 Feb 17;27(2):304-308. doi: 10.1021/tx4004374. Epub 2014 Feb 5. Chem Res Toxicol. 2014. PMID: 24460184 Free PMC article.

8

The reconstituted 'humanized liver' in TK-NOG mice is mature and functional.

Hasegawa M, Kawai K, Mitsui T, Taniguchi K, Monnai M, Wakui M, Ito M, Suematsu M, Peltz G, Nakamura M, Suemizu H. Hasegawa M, et al. Among authors: nakamura m. Biochem Biophys Res Commun. 2011 Feb 18;405(3):405-10. doi: 10.1016/j.bbrc.2011.01.042. Epub 2011 Jan 14. Biochem Biophys Res Commun. 2011. PMID: 21238430 Free PMC article.

9

Novel metastasis models of human cancer in NOG mice.

Nakamura M, Suemizu H. Nakamura M, et al. Curr Top Microbiol Immunol. 2008;324:167-77. doi: 10.1007/978-3-540-75647-7_11. Curr Top Microbiol Immunol. 2008. PMID: 18481460 Review.

10

Establishment of a humanized model of liver using NOD/Shi-scid IL2Rgnull mice.

Suemizu H, Hasegawa M, Kawai K, Taniguchi K, Monnai M, Wakui M, Suematsu M, Ito M, Peltz G, Nakamura M. Suemizu H, et al. Among authors: nakamura m. Biochem Biophys Res Commun. 2008 Dec 5;377(1):248-52. doi: 10.1016/j.bbrc.2008.09.124. Epub 2008 Oct 7. Biochem Biophys Res Commun. 2008. PMID: 18840406

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