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Electrostatic sheathing of lipoprotein lipase is essential for its movement across capillary endothelial cells.
Song W, Beigneux AP, Winther AL, Kristensen KK, Grønnemose AL, Yang Y, Tu Y, Munguia P, Morales J, Jung H, de Jong PJ, Jung CJ, Miyashita K, Kimura T, Nakajima K, Murakami M, Birrane G, Jiang H, Tontonoz P, Ploug M, Fong LG, Young SG. Song W, et al. Among authors: nakajima k. J Clin Invest. 2022 Mar 1;132(5):e157500. doi: 10.1172/JCI157500. J Clin Invest. 2022. PMID: 35229724 Free PMC article.
An LPL-specific monoclonal antibody, 88B8, that abolishes the binding of LPL to GPIHBP1.
Allan CM, Larsson M, Hu X, He C, Jung RS, Mapar A, Voss C, Miyashita K, Machida T, Murakami M, Nakajima K, Bensadoun A, Ploug M, Fong LG, Young SG, Beigneux AP. Allan CM, et al. Among authors: nakajima k. J Lipid Res. 2016 Oct;57(10):1889-1898. doi: 10.1194/jlr.M070813. Epub 2016 Aug 5. J Lipid Res. 2016. PMID: 27494936 Free PMC article.
Monoclonal antibodies that bind to the Ly6 domain of GPIHBP1 abolish the binding of LPL.
Hu X, Sleeman MW, Miyashita K, Linton MF, Allan CM, He C, Larsson M, Tu Y, Sandoval NP, Jung RS, Mapar A, Machida T, Murakami M, Nakajima K, Ploug M, Fong LG, Young SG, Beigneux AP. Hu X, et al. Among authors: nakajima k. J Lipid Res. 2017 Jan;58(1):208-215. doi: 10.1194/jlr.M072462. Epub 2016 Nov 15. J Lipid Res. 2017. PMID: 27875259 Free PMC article.
GPIHBP1 autoantibodies in a patient with unexplained chylomicronemia.
Hu X, Dallinga-Thie GM, Hovingh GK, Chang SY, Sandoval NP, Dang TLP, Fukamachi I, Miyashita K, Nakajima K, Murakami M, Fong LG, Ploug M, Young SG, Beigneux AP. Hu X, et al. Among authors: nakajima k. J Clin Lipidol. 2017 Jul-Aug;11(4):964-971. doi: 10.1016/j.jacl.2017.05.017. Epub 2017 Jun 13. J Clin Lipidol. 2017. PMID: 28666713 Free PMC article.
Lipoprotein lipase is active as a monomer.
Beigneux AP, Allan CM, Sandoval NP, Cho GW, Heizer PJ, Jung RS, Stanhope KL, Havel PJ, Birrane G, Meiyappan M, Gill JE 4th, Murakami M, Miyashita K, Nakajima K, Ploug M, Fong LG, Young SG. Beigneux AP, et al. Among authors: nakajima k. Proc Natl Acad Sci U S A. 2019 Mar 26;116(13):6319-6328. doi: 10.1073/pnas.1900983116. Epub 2019 Mar 8. Proc Natl Acad Sci U S A. 2019. PMID: 30850549 Free PMC article.
GPIHBP1 and Lipoprotein Lipase, Partners in Plasma Triglyceride Metabolism.
Young SG, Fong LG, Beigneux AP, Allan CM, He C, Jiang H, Nakajima K, Meiyappan M, Birrane G, Ploug M. Young SG, et al. Among authors: nakajima k. Cell Metab. 2019 Jul 2;30(1):51-65. doi: 10.1016/j.cmet.2019.05.023. Cell Metab. 2019. PMID: 31269429 Free PMC article. Review.
Intermittent chylomicronemia caused by intermittent GPIHBP1 autoantibodies.
Ashraf AP, Miyashita K, Nakajima K, Murakami M, Hegele RA, Ploug M, Fong LG, Young SG, Beigneux AP. Ashraf AP, et al. Among authors: nakajima k. J Clin Lipidol. 2020 Mar-Apr;14(2):197-200. doi: 10.1016/j.jacl.2020.01.012. Epub 2020 Jan 31. J Clin Lipidol. 2020. PMID: 32107180 Free PMC article.
Chylomicronemia from GPIHBP1 autoantibodies.
Miyashita K, Lutz J, Hudgins LC, Toib D, Ashraf AP, Song W, Murakami M, Nakajima K, Ploug M, Fong LG, Young SG, Beigneux AP. Miyashita K, et al. Among authors: nakajima k. J Lipid Res. 2020 Nov;61(11):1365-1376. doi: 10.1194/jlr.R120001116. Epub 2020 Sep 18. J Lipid Res. 2020. PMID: 32948662 Free PMC article. Review.
4,930 results