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Managing the challenge of chemically reactive metabolites in drug development.
Park BK, Boobis A, Clarke S, Goldring CE, Jones D, Kenna JG, Lambert C, Laverty HG, Naisbitt DJ, Nelson S, Nicoll-Griffith DA, Obach RS, Routledge P, Smith DA, Tweedie DJ, Vermeulen N, Williams DP, Wilson ID, Baillie TA. Park BK, et al. Among authors: naisbitt dj. Nat Rev Drug Discov. 2011 Apr;10(4):292-306. doi: 10.1038/nrd3408. Nat Rev Drug Discov. 2011. PMID: 21455238 Review.
Direct evidence for the formation of diastereoisomeric benzylpenicilloyl haptens from benzylpenicillin and benzylpenicillenic acid in patients.
Meng X, Jenkins RE, Berry NG, Maggs JL, Farrell J, Lane CS, Stachulski AV, French NS, Naisbitt DJ, Pirmohamed M, Park BK. Meng X, et al. Among authors: naisbitt dj. J Pharmacol Exp Ther. 2011 Sep;338(3):841-9. doi: 10.1124/jpet.111.183871. Epub 2011 Jun 16. J Pharmacol Exp Ther. 2011. PMID: 21680886 Free PMC article.
Characterization of the antigen specificity of T-cell clones from piperacillin-hypersensitive patients with cystic fibrosis.
El-Ghaiesh S, Monshi MM, Whitaker P, Jenkins R, Meng X, Farrell J, Elsheikh A, Peckham D, French N, Pirmohamed M, Park BK, Naisbitt DJ. El-Ghaiesh S, et al. Among authors: naisbitt dj. J Pharmacol Exp Ther. 2012 Jun;341(3):597-610. doi: 10.1124/jpet.111.190900. Epub 2012 Feb 27. J Pharmacol Exp Ther. 2012. PMID: 22371438 Free PMC article.
β-Lactam antibiotics form distinct haptenic structures on albumin and activate drug-specific T-lymphocyte responses in multiallergic patients with cystic fibrosis.
Jenkins RE, Yaseen FS, Monshi MM, Whitaker P, Meng X, Farrell J, Hamlett J, Sanderson JP, El-Ghaiesh S, Peckham D, Pirmohamed M, Park BK, Naisbitt DJ. Jenkins RE, et al. Among authors: naisbitt dj. Chem Res Toxicol. 2013 Jun 17;26(6):963-75. doi: 10.1021/tx400124m. Epub 2013 May 23. Chem Res Toxicol. 2013. PMID: 23668298
Abacavir forms novel cross-linking abacavir protein adducts in patients.
Meng X, Lawrenson AS, Berry NG, Maggs JL, French NS, Back DJ, Khoo SH, Naisbitt DJ, Park BK. Meng X, et al. Among authors: naisbitt dj. Chem Res Toxicol. 2014 Apr 21;27(4):524-35. doi: 10.1021/tx400406p. Epub 2014 Feb 26. Chem Res Toxicol. 2014. PMID: 24571427
182 results