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Dual blockade of IL-4 and IL-13 with dupilumab, an IL-4Rα antibody, is required to broadly inhibit type 2 inflammation.
Le Floc'h A, Allinne J, Nagashima K, Scott G, Birchard D, Asrat S, Bai Y, Lim WK, Martin J, Huang T, Potocky TB, Kim JH, Rafique A, Papadopoulos NJ, Stahl N, Yancopoulos GD, Murphy AJ, Sleeman MA, Orengo JM. Le Floc'h A, et al. Among authors: nagashima k. Allergy. 2020 May;75(5):1188-1204. doi: 10.1111/all.14151. Epub 2020 Jan 3. Allergy. 2020. PMID: 31838750 Free PMC article.
IL-4 and IL-13, not eosinophils, drive type 2 airway inflammation, remodeling and lung function decline.
Scott G, Asrat S, Allinne J, Keat Lim W, Nagashima K, Birchard D, Srivatsan S, Ajithdoss DK, Oyejide A, Ben LH, Walls J, Le Floc'h A, Yancopoulos GD, Murphy AJ, Sleeman MA, Orengo JM. Scott G, et al. Among authors: nagashima k. Cytokine. 2023 Feb;162:156091. doi: 10.1016/j.cyto.2022.156091. Epub 2022 Dec 5. Cytokine. 2023. PMID: 36481478 Free article.
Blocking common γ chain cytokine signaling ameliorates T cell-mediated pathogenesis in disease models.
Le Floc'h A, Nagashima K, Birchard D, Scott G, Ben LH, Ajithdoss D, Gayvert K, Romero Hernandez A, Herbin O, Tay A, Farrales P, Korgaonkar CK, Pan H, Shah S, Kamat V, Chatterjee I, Popke J, Oyejide A, Lim WK, Kim JH, Huang T, Franklin M, Olson W, Norton T, Perlee L, Yancopoulos GD, Murphy AJ, Sleeman MA, Orengo JM. Le Floc'h A, et al. Among authors: nagashima k. Sci Transl Med. 2023 Jan 11;15(678):eabo0205. doi: 10.1126/scitranslmed.abo0205. Epub 2023 Jan 11. Sci Transl Med. 2023. PMID: 36630481
Chiral Transfer of Linear Polysiloxane with Preferred-Handed Helical Conformation.
Mure T, Kinoshita Y, Sakai H, Morii S, Wu HN, Yung TM, Yu HC, Nagashima K, Higashiguchi W, Ohta N, Hayakawa T, Nakamura Y, Fujii S, Li MC, Hirai T. Mure T, et al. Among authors: nagashima k. ACS Macro Lett. 2024 Apr 17:537-541. doi: 10.1021/acsmacrolett.4c00122. Online ahead of print. ACS Macro Lett. 2024. PMID: 38629809
Risk factors for recurrence in patients with hormone receptor-positive/human epidermal growth factor receptor 2-negative early breast cancer in Japan: a systematic literature review and meta-analysis.
Miyazaki N, Iwasaki T, Sakai H, Watanuki R, Tanizawa Y, Cai Z, Kawaguchi T, Tsurutani J, Nagashima K. Miyazaki N, et al. Among authors: nagashima k. Curr Med Res Opin. 2024 May;40(5):827-837. doi: 10.1080/03007995.2024.2332436. Epub 2024 Apr 10. Curr Med Res Opin. 2024. PMID: 38597173 Review.
1,940 results