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Targeted activation of human ether-à-go-go-related gene channels rescues electrical instability induced by the R56Q+/- long QT syndrome variant.
Venkateshappa R, Hunter DV, Muralidharan P, Nagalingam RS, Huen G, Faizi S, Luthra S, Lin E, Cheng YM, Hughes J, Khelifi R, Dhunna DP, Johal R, Sergeev V, Shafaattalab S, Julian LM, Poburko DT, Laksman Z, Tibbits GF, Claydon TW. Venkateshappa R, et al. Among authors: nagalingam rs. Cardiovasc Res. 2023 Nov 25;119(15):2522-2535. doi: 10.1093/cvr/cvad155. Cardiovasc Res. 2023. PMID: 37739930
Mechanisms of Pathogenicity of Hypertrophic Cardiomyopathy-Associated Troponin T (TNNT2) Variant R278C+/- During Development.
Shafaattalab S, Li AY, Jayousi F, Maaref Y, Dababneh S, Hamledari H, Baygi DH, Barszczewski T, Ruprai B, Jannati S, Nagalingam R, Cool AM, Langa P, Chiao M, Roston T, Solaro RJ, Sanatani S, Toepfer C, Lindert S, Lange P, Tibbits GF. Shafaattalab S, et al. Among authors: nagalingam r. bioRxiv [Preprint]. 2023 Aug 13:2023.06.06.542948. doi: 10.1101/2023.06.06.542948. bioRxiv. 2023. PMID: 37609317 Free PMC article. Preprint.
Scleraxis and fibrosis in the pressure-overloaded heart.
Nagalingam RS, Chattopadhyaya S, Al-Hattab DS, Cheung DYC, Schwartz LY, Jana S, Aroutiounova N, Ledingham DA, Moffatt TL, Landry NM, Bagchi RA, Dixon IMC, Wigle JT, Oudit GY, Kassiri Z, Jassal DS, Czubryt MP. Nagalingam RS, et al. Eur Heart J. 2022 Dec 1;43(45):4739-4750. doi: 10.1093/eurheartj/ehac362. Eur Heart J. 2022. PMID: 36200607
Regulation of Cardiac Fibroblast GLS1 Expression by Scleraxis.
Chattopadhyaya S, Nagalingam RS, Ledingham DA, Moffatt TL, Al-Hattab DS, Narhan P, Stecy MT, O'Hara KA, Czubryt MP. Chattopadhyaya S, et al. Among authors: nagalingam rs. Cells. 2022 Apr 27;11(9):1471. doi: 10.3390/cells11091471. Cells. 2022. PMID: 35563778 Free PMC article.
CEBPβ regulation of endogenous IGF-1 in adult sensory neurons can be mobilized to overcome diabetes-induced deficits in bioenergetics and axonal outgrowth.
Aghanoori MR, Agarwal P, Gauvin E, Nagalingam RS, Bonomo R, Yathindranath V, Smith DR, Hai Y, Lee S, Jolivalt CG, Calcutt NA, Jones MJ, Czubryt MP, Miller DW, Dolinsky VW, Mansuy-Aubert V, Fernyhough P. Aghanoori MR, et al. Among authors: nagalingam rs. Cell Mol Life Sci. 2022 Mar 17;79(4):193. doi: 10.1007/s00018-022-04201-9. Cell Mol Life Sci. 2022. PMID: 35298717 Free PMC article.
Elimination of endogenous high molecular weight FGF2 prevents pressure-overload-induced systolic dysfunction, linked to increased FGFR1 activity and NR1D1 expression.
Koleini N, Nickel BE, Nagalingam RS, Landry NM, Fandrich RR, Cheung DYC, Dixon IM, Czubryt MP, Jassal DS, Cattini PA, Kardami E. Koleini N, et al. Among authors: nagalingam rs. Cell Tissue Res. 2021 Sep;385(3):753-768. doi: 10.1007/s00441-021-03465-0. Epub 2021 May 31. Cell Tissue Res. 2021. PMID: 34057573
What's in a name? On fibroblast phenotype and nomenclature 1.
Nagalingam RS, Al-Hattab DS, Czubryt MP. Nagalingam RS, et al. Can J Physiol Pharmacol. 2019 Jun;97(6):493-497. doi: 10.1139/cjpp-2018-0555. Epub 2018 Nov 23. Can J Physiol Pharmacol. 2019. PMID: 30468625 Review.
Regulation of cardiac fibroblast MMP2 gene expression by scleraxis.
Nagalingam RS, Safi HA, Al-Hattab DS, Bagchi RA, Landry NM, Dixon IMC, Wigle JT, Czubryt MP. Nagalingam RS, et al. J Mol Cell Cardiol. 2018 Jul;120:64-73. doi: 10.1016/j.yjmcc.2018.05.004. Epub 2018 May 8. J Mol Cell Cardiol. 2018. PMID: 29750994
22 results