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Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease.
Chalupova K, Korabecny J, Bartolini M, Monti B, Lamba D, Caliandro R, Pesaresi A, Brazzolotto X, Gastellier AJ, Nachon F, Pejchal J, Jarosova M, Hepnarova V, Jun D, Hrabinova M, Dolezal R, Zdarova Karasova J, Mzik M, Kristofikova Z, Misik J, Muckova L, Jost P, Soukup O, Benkova M, Setnicka V, Habartova L, Chvojkova M, Kleteckova L, Vales K, Mezeiova E, Uliassi E, Valis M, Nepovimova E, Bolognesi ML, Kuca K. Chalupova K, et al. Among authors: nachon f. Eur J Med Chem. 2019 Apr 15;168:491-514. doi: 10.1016/j.ejmech.2019.02.021. Epub 2019 Feb 27. Eur J Med Chem. 2019. PMID: 30851693
Preparation and in vitro screening of symmetrical bispyridinium cholinesterase inhibitors bearing different connecting linkage-initial study for Myasthenia gravis implications.
Musilek K, Komloova M, Zavadova V, Holas O, Hrabinova M, Pohanka M, Dohnal V, Nachon F, Dolezal M, Kuca K, Jung YS. Musilek K, et al. Among authors: nachon f. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1763-6. doi: 10.1016/j.bmcl.2010.01.034. Epub 2010 Jan 20. Bioorg Med Chem Lett. 2010. PMID: 20138518
Synthesis and in vitro evaluation of N-(Bromobut-3-en-2-yl)-7-methoxy-1,2,3,4-tetrahydroacridin-9-amine as a cholinesterase inhibitor with regard to Alzheimer's disease treatment.
Korabecny J, Musilek K, Holas O, Nepovimova E, Jun D, Zemek F, Opletalova V, Patocka J, Dohnal V, Nachon F, Hroudova J, Fisar Z, Kuca K. Korabecny J, et al. Among authors: nachon f. Molecules. 2010 Dec 2;15(12):8804-12. doi: 10.3390/molecules15128804. Molecules. 2010. PMID: 21127466 Free PMC article.
Organophosphate hydrolases as catalytic bioscavengers of organophosphorus nerve agents.
Trovaslet-Leroy M, Musilova L, Renault F, Brazzolotto X, Misik J, Novotny L, Froment MT, Gillon E, Loiodice M, Verdier L, Masson P, Rochu D, Jun D, Nachon F. Trovaslet-Leroy M, et al. Among authors: nachon f. Toxicol Lett. 2011 Sep 25;206(1):14-23. doi: 10.1016/j.toxlet.2011.05.1041. Epub 2011 Jun 12. Toxicol Lett. 2011. PMID: 21683774
Design, synthesis and biological evaluation of novel tetrahydroacridine pyridine- aldoxime and -amidoxime hybrids as efficient uncharged reactivators of nerve agent-inhibited human acetylcholinesterase.
Kliachyna M, Santoni G, Nussbaum V, Renou J, Sanson B, Colletier JP, Arboléas M, Loiodice M, Weik M, Jean L, Renard PY, Nachon F, Baati R. Kliachyna M, et al. Among authors: nachon f. Eur J Med Chem. 2014 May 6;78:455-67. doi: 10.1016/j.ejmech.2014.03.044. Epub 2014 Mar 15. Eur J Med Chem. 2014. PMID: 24704618
135 results