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Generating and Utilizing Murine Cas9-Expressing Intestinal Organoids for Large-Scale Knockout Genetic Screening.
Kashfi H, Jinks N, Nateri AS. Kashfi H, et al. Methods Mol Biol. 2020;2171:257-269. doi: 10.1007/978-1-0716-0747-3_17. Methods Mol Biol. 2020. PMID: 32705648
Knockout intestinal organoids can be associated with the key biological function of the gene(s) in development, homeostasis, disease progression, tumorigenesis, and drug screening, thereby reducing and potentially replacing animal models....
Knockout intestinal organoids can be associated with the key biological function of the gene(s) in development, homeostasis, disease progres …
Morphological alterations of cultured human colorectal matched tumour and healthy organoids.
Kashfi SMH, Almozyan S, Jinks N, Koo BK, Nateri AS. Kashfi SMH, et al. Oncotarget. 2018 Jan 19;9(12):10572-10584. doi: 10.18632/oncotarget.24279. eCollection 2018 Feb 13. Oncotarget. 2018. PMID: 29535828 Free PMC article.
Thus, while their specific structural features provide valuable in vitro models to study various aspects of human intestinal/colon tissue homeostasis and CRC which avoid or replace the use of animals in research, this model may also hold a great promise for the transplanta …
Thus, while their specific structural features provide valuable in vitro models to study various aspects of human intestinal/colon tissue ho …