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Optimization of the Enrichment of Circulating Tumor Cells for Downstream Phenotypic Analysis in Patients with Non-Small Cell Lung Cancer Treated with Anti-PD-1 Immunotherapy.
Papadaki MA, Sotiriou AI, Vasilopoulou C, Filika M, Aggouraki D, Tsoulfas PG, Apostolopoulou CA, Rounis K, Mavroudis D, Agelaki S. Papadaki MA, et al. Cancers (Basel). 2020 Jun 12;12(6):1556. doi: 10.3390/cancers12061556. Cancers (Basel). 2020. PMID: 32545559 Free PMC article.
IDO and PD-L1 were expressed in 44% and 33% and co-expressed in 19% of CTCs. CTC detection was associated with progressive disease (PD) (p = 0.006), reduced progression-free survival PFS (p = 0.007), and increased risk of relapse (hazard ratio; HR: 10.733; p = 0.026). IDO- …
IDO and PD-L1 were expressed in 44% and 33% and co-expressed in 19% of CTCs. CTC detection was associated with progressive disease (P …
Clinical Relevance of Immune Checkpoints on Circulating Tumor Cells in Breast Cancer.
Papadaki MA, Koutsopoulos AV, Tsoulfas PG, Lagoudaki E, Aggouraki D, Monastirioti A, Koutoulaki C, Apostolopoulou CA, Merodoulaki AC, Papadaki C, Mavroudis D, Agelaki S. Papadaki MA, et al. Cancers (Basel). 2020 Feb 6;12(2):376. doi: 10.3390/cancers12020376. Cancers (Basel). 2020. PMID: 32041353 Free PMC article.
In metastatic disease, CD47(high)and/orPD-L1(high) CTCs were associated with disease progression (p = 0.005) and shorter progression-free survival (PFS) (p = 0.010), and independently predicted for an increased risk of relapse (HR: 2.719; p = 0.008) and death (HR: 2.398; p …
In metastatic disease, CD47(high)and/orPD-L1(high) CTCs were associated with disease progression (p = 0.005) and shorter progression- …