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The glucose-sensing transcription factor ChREBP is targeted by proline hydroxylation.
Heidenreich S, Weber P, Stephanowitz H, Petricek KM, Schütte T, Oster M, Salo AM, Knauer M, Goehring I, Yang N, Witte N, Schumann A, Sommerfeld M, Muenzner M, Myllyharju J, Krause E, Schupp M. Heidenreich S, et al. Among authors: myllyharju j. J Biol Chem. 2020 Dec 11;295(50):17158-17168. doi: 10.1074/jbc.RA120.014402. Epub 2020 Oct 6. J Biol Chem. 2020. PMID: 33023907 Free PMC article.
Characterization of human type III collagen expressed in a baculovirus system. Production of a protein with a stable triple helix requires coexpression with the two types of recombinant prolyl 4-hydroxylase subunit.
Lamberg A, Helaakoski T, Myllyharju J, Peltonen S, Notbohm H, Pihlajaniemi T, Kivirikko KI. Lamberg A, et al. Among authors: myllyharju j. J Biol Chem. 1996 May 17;271(20):11988-95. doi: 10.1074/jbc.271.20.11988. J Biol Chem. 1996. PMID: 8662631 Free article.
Collagen prolyl 4-hydroxylase tetramers and dimers show identical decreases in Km values for peptide substrates with increasing chain length: mutation of one of the two catalytic sites in the tetramer inactivates the enzyme by more than half.
Kukkola L, Koivunen P, Pakkanen O, Page AP, Myllyharju J. Kukkola L, et al. Among authors: myllyharju j. J Biol Chem. 2004 Apr 30;279(18):18656-61. doi: 10.1074/jbc.M401514200. Epub 2004 Feb 25. J Biol Chem. 2004. PMID: 14985345 Free article.
148 results