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Structure-Guided Design and Synthesis of a Pyridazinone Series of Trypanosoma cruzi Proteasome Inhibitors.
Thomas MG, McGonagle K, Rowland P, Robinson DA, Dodd PG, Camino-Díaz I, Campbell L, Cantizani J, Castañeda P, Conn D, Craggs PD, Edwards D, Ferguson L, Fosberry A, Frame L, Goswami P, Hu X, Korczynska J, MacLean L, Martin J, Mutter N, Osuna-Cabello M, Paterson C, Peña I, Pinto EG, Pont C, Riley J, Shishikura Y, Simeons FRC, Stojanovski L, Thomas J, Wrobel K, Young RJ, Zmuda F, Zuccotto F, Read KD, Gilbert IH, Marco M, Miles TJ, Manzano P, De Rycker M. Thomas MG, et al. Among authors: mutter n. J Med Chem. 2023 Aug 10;66(15):10413-10431. doi: 10.1021/acs.jmedchem.3c00582. Epub 2023 Jul 28. J Med Chem. 2023. PMID: 37506194 Free PMC article.
Visible Light Control over the Cytolytic Activity of a Toxic Pore-Forming Protein.
Volarić J, van der Heide NJ, Mutter NL, Samplonius DF, Helfrich W, Maglia G, Szymanski W, Feringa BL. Volarić J, et al. Among authors: mutter nl. ACS Chem Biol. 2024 Feb 16;19(2):451-461. doi: 10.1021/acschembio.3c00640. Epub 2024 Feb 6. ACS Chem Biol. 2024. PMID: 38318850 Free PMC article.
Acceleration of infectious disease drug discovery and development using a humanized model of drug metabolism.
MacLeod AK, Coquelin KS, Huertas L, Simeons FRC, Riley J, Casado P, Guijarro L, Casanueva R, Frame L, Pinto EG, Ferguson L, Duncan C, Mutter N, Shishikura Y, Henderson CJ, Cebrian D, Wolf CR, Read KD. MacLeod AK, et al. Among authors: mutter n. Proc Natl Acad Sci U S A. 2024 Feb 13;121(7):e2315069121. doi: 10.1073/pnas.2315069121. Epub 2024 Feb 5. Proc Natl Acad Sci U S A. 2024. PMID: 38315851 Free PMC article.
Preparation of Cytolysin A (ClyA) Nanopores.
Galenkamp NS, Van Meervelt V, Mutter NL, van der Heide NJ, Wloka C, Maglia G. Galenkamp NS, et al. Among authors: mutter nl. Methods Mol Biol. 2021;2186:11-18. doi: 10.1007/978-1-0716-0806-7_2. Methods Mol Biol. 2021. PMID: 32918726
21 results