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Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold-Based DNA Gyrase Inhibitors with Potent Activity against Acinetobacter baumannii and Pseudomonas aeruginosa.
J Med Chem. 2023 Jan 26;66(2):1380-1425. doi: 10.1021/acs.jmedchem.2c01597. Epub 2023 Jan 12.
J Med Chem. 2023.
PMID: 36634346
Free PMC article.
Exploring the Chemical Space of Benzothiazole-Based DNA Gyrase B Inhibitors.
Skok Ž, Barančoková M, Benek O, Cruz CD, Tammela P, Tomašič T, Zidar N, Mašič LP, Zega A, Stevenson CEM, Mundy JEA, Lawson DM, Maxwell A, Kikelj D, Ilaš J.
Skok Ž, et al. Among authors: mundy jea.
ACS Med Chem Lett. 2020 Oct 15;11(12):2433-2440. doi: 10.1021/acsmedchemlett.0c00416. eCollection 2020 Dec 10.
ACS Med Chem Lett. 2020.
PMID: 33329764
Free PMC article.
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The pentapeptide-repeat protein, MfpA, interacts with mycobacterial DNA gyrase as a DNA T-segment mimic.
Feng L, Mundy JEA, Stevenson CEM, Mitchenall LA, Lawson DM, Mi K, Maxwell A.
Feng L, et al. Among authors: mundy jea.
Proc Natl Acad Sci U S A. 2021 Mar 16;118(11):e2016705118. doi: 10.1073/pnas.2016705118.
Proc Natl Acad Sci U S A. 2021.
PMID: 33836580
Free PMC article.
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New Dual Inhibitors of Bacterial Topoisomerases with Broad-Spectrum Antibacterial Activity and In Vivo Efficacy against Vancomycin-Intermediate Staphylococcus aureus.
Durcik M, Cotman AE, Toplak Ž, Možina Š, Skok Ž, Szili PE, Czikkely M, Maharramov E, Vu TH, Piras MV, Zidar N, Ilaš J, Zega A, Trontelj J, Pardo LA, Hughes D, Huseby D, Berruga-Fernández T, Cao S, Simoff I, Svensson R, Korol SV, Jin Z, Vicente F, Ramos MC, Mundy JEA, Maxwell A, Stevenson CEM, Lawson DM, Glinghammar B, Sjöström E, Bohlin M, Oreskär J, Alvér S, Janssen GV, Sterk GJ, Kikelj D, Pal C, Tomašič T, Peterlin Mašič L.
Durcik M, et al. Among authors: mundy jea.
J Med Chem. 2023 Mar 23;66(6):3968-3994. doi: 10.1021/acs.jmedchem.2c01905. Epub 2023 Mar 6.
J Med Chem. 2023.
PMID: 36877255
Free PMC article.
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Biosynthesis of an Anti-Addiction Agent from the Iboga Plant.
Farrow SC, Kamileen MO, Caputi L, Bussey K, Mundy JEA, McAtee RC, Stephenson CRJ, O'Connor SE.
Farrow SC, et al. Among authors: mundy jea.
J Am Chem Soc. 2019 Aug 21;141(33):12979-12983. doi: 10.1021/jacs.9b05999. Epub 2019 Aug 6.
J Am Chem Soc. 2019.
PMID: 31364847
Free PMC article.
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