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Baeyer-Villiger Monooxygenase-Mediated Synthesis of Esomeprazole As an Alternative for Kagan Sulfoxidation.
Bong YK, Song S, Nazor J, Vogel M, Widegren M, Smith D, Collier SJ, Wilson R, Palanivel SM, Narayanaswamy K, Mijts B, Clay MD, Fong R, Colbeck J, Appaswami A, Muley S, Zhu J, Zhang X, Liang J, Entwistle D. Bong YK, et al. Among authors: muley s. J Org Chem. 2018 Jul 20;83(14):7453-7458. doi: 10.1021/acs.joc.8b00468. Epub 2018 Jun 22. J Org Chem. 2018. PMID: 29932340
Efficient, chemoenzymatic process for manufacture of the Boceprevir bicyclic [3.1.0]proline intermediate based on amine oxidase-catalyzed desymmetrization.
Li T, Liang J, Ambrogelly A, Brennan T, Gloor G, Huisman G, Lalonde J, Lekhal A, Mijts B, Muley S, Newman L, Tobin M, Wong G, Zaks A, Zhang X. Li T, et al. Among authors: muley s. J Am Chem Soc. 2012 Apr 11;134(14):6467-72. doi: 10.1021/ja3010495. Epub 2012 Mar 28. J Am Chem Soc. 2012. PMID: 22409428
Improving catalytic function by ProSAR-driven enzyme evolution.
Fox RJ, Davis SC, Mundorff EC, Newman LM, Gavrilovic V, Ma SK, Chung LM, Ching C, Tam S, Muley S, Grate J, Gruber J, Whitman JC, Sheldon RA, Huisman GW. Fox RJ, et al. Among authors: muley s. Nat Biotechnol. 2007 Mar;25(3):338-44. doi: 10.1038/nbt1286. Epub 2007 Feb 18. Nat Biotechnol. 2007. PMID: 17322872
48 results