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Tacrine - Benzothiazoles: Novel class of potential multitarget anti-Alzheimeŕs drugs dealing with cholinergic, amyloid and mitochondrial systems.
Nepovimova E, Svobodova L, Dolezal R, Hepnarova V, Junova L, Jun D, Korabecny J, Kucera T, Gazova Z, Motykova K, Kubackova J, Bednarikova Z, Janockova J, Jesus C, Cortes L, Pina J, Rostohar D, Serpa C, Soukup O, Aitken L, Hughes RE, Musilek K, Muckova L, Jost P, Chvojkova M, Vales K, Valis M, Chrienova Z, Chalupova K, Kuca K. Nepovimova E, et al. Among authors: muckova l. Bioorg Chem. 2021 Feb;107:104596. doi: 10.1016/j.bioorg.2020.104596. Epub 2020 Dec 28. Bioorg Chem. 2021. PMID: 33421953
Tacrine-Trolox Hybrids: A Novel Class of Centrally Active, Nonhepatotoxic Multi-Target-Directed Ligands Exerting Anticholinesterase and Antioxidant Activities with Low In Vivo Toxicity.
Nepovimova E, Korabecny J, Dolezal R, Babkova K, Ondrejicek A, Jun D, Sepsova V, Horova A, Hrabinova M, Soukup O, Bukum N, Jost P, Muckova L, Kassa J, Malinak D, Andrs M, Kuca K. Nepovimova E, et al. Among authors: muckova l. J Med Chem. 2015 Nov 25;58(22):8985-9003. doi: 10.1021/acs.jmedchem.5b01325. Epub 2015 Nov 10. J Med Chem. 2015. PMID: 26503905
Development of 2-Methoxyhuprine as Novel Lead for Alzheimer's Disease Therapy.
Mezeiova E, Korabecny J, Sepsova V, Hrabinova M, Jost P, Muckova L, Kucera T, Dolezal R, Misik J, Spilovska K, Pham NL, Pokrievkova L, Roh J, Jun D, Soukup O, Kaping D, Kuca K. Mezeiova E, et al. Among authors: muckova l. Molecules. 2017 Jul 28;22(8):1265. doi: 10.3390/molecules22081265. Molecules. 2017. PMID: 28788095 Free PMC article.
The concept of hybrid molecules of tacrine and benzyl quinolone carboxylic acid (BQCA) as multifunctional agents for Alzheimer's disease.
Hepnarova V, Korabecny J, Matouskova L, Jost P, Muckova L, Hrabinova M, Vykoukalova N, Kerhartova M, Kucera T, Dolezal R, Nepovimova E, Spilovska K, Mezeiova E, Pham NL, Jun D, Staud F, Kaping D, Kuca K, Soukup O. Hepnarova V, et al. Among authors: muckova l. Eur J Med Chem. 2018 Apr 25;150:292-306. doi: 10.1016/j.ejmech.2018.02.083. Epub 2018 Mar 2. Eur J Med Chem. 2018. PMID: 29533874
A 7-methoxytacrine-4-pyridinealdoxime hybrid as a novel prophylactic agent with reactivation properties in organophosphate intoxication.
Nepovimova E, Korabecny J, Dolezal R, Nguyen TD, Jun D, Soukup O, Pasdiorova M, Jost P, Muckova L, Malinak D, Gorecki L, Musilek K, Kuca K. Nepovimova E, et al. Among authors: muckova l. Toxicol Res (Camb). 2016 May 25;5(4):1012-1016. doi: 10.1039/c6tx00130k. eCollection 2016 Jul 1. Toxicol Res (Camb). 2016. PMID: 30090408 Free PMC article.
Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease.
Chalupova K, Korabecny J, Bartolini M, Monti B, Lamba D, Caliandro R, Pesaresi A, Brazzolotto X, Gastellier AJ, Nachon F, Pejchal J, Jarosova M, Hepnarova V, Jun D, Hrabinova M, Dolezal R, Zdarova Karasova J, Mzik M, Kristofikova Z, Misik J, Muckova L, Jost P, Soukup O, Benkova M, Setnicka V, Habartova L, Chvojkova M, Kleteckova L, Vales K, Mezeiova E, Uliassi E, Valis M, Nepovimova E, Bolognesi ML, Kuca K. Chalupova K, et al. Among authors: muckova l. Eur J Med Chem. 2019 Apr 15;168:491-514. doi: 10.1016/j.ejmech.2019.02.021. Epub 2019 Feb 27. Eur J Med Chem. 2019. PMID: 30851693
41 results