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IL-1β+ macrophages fuel pathogenic inflammation in pancreatic cancer.
Caronni N, La Terza F, Vittoria FM, Barbiera G, Mezzanzanica L, Cuzzola V, Barresi S, Pellegatta M, Canevazzi P, Dunsmore G, Leonardi C, Montaldo E, Lusito E, Dugnani E, Citro A, Ng MSF, Schiavo Lena M, Drago D, Andolfo A, Brugiapaglia S, Scagliotti A, Mortellaro A, Corbo V, Liu Z, Mondino A, Dellabona P, Piemonti L, Taveggia C, Doglioni C, Cappello P, Novelli F, Iannacone M, Ng LG, Ginhoux F, Crippa S, Falconi M, Bonini C, Naldini L, Genua M, Ostuni R. Caronni N, et al. Among authors: mortellaro a. Nature. 2023 Nov;623(7986):415-422. doi: 10.1038/s41586-023-06685-2. Epub 2023 Nov 1. Nature. 2023. PMID: 37914939 Free article.
Constitutive IL-1RA production by modified immune cells protects against IL-1-mediated inflammatory disorders.
Colantuoni M, Jofra Hernandez R, Pettinato E, Basso-Ricci L, Magnani L, Andolfi G, Rigamonti C, Finardi A, Romeo V, Soldi M, Sergi Sergi L, Rocchi M, Scala S, Hoffman HM, Gregori S, Kajaste-Rudnitski A, Sanvito F, Muzio L, Naldini L, Aiuti A, Mortellaro A. Colantuoni M, et al. Among authors: mortellaro a. Sci Transl Med. 2023 May 31;15(698):eade3856. doi: 10.1126/scitranslmed.ade3856. Epub 2023 May 31. Sci Transl Med. 2023. PMID: 37256935
Ex vivo gene therapy with lentiviral vectors rescues adenosine deaminase (ADA)-deficient mice and corrects their immune and metabolic defects.
Mortellaro A, Hernandez RJ, Guerrini MM, Carlucci F, Tabucchi A, Ponzoni M, Sanvito F, Doglioni C, Di Serio C, Biasco L, Follenzi A, Naldini L, Bordignon C, Roncarolo MG, Aiuti A. Mortellaro A, et al. Blood. 2006 Nov 1;108(9):2979-88. doi: 10.1182/blood-2006-05-023507. Epub 2006 Jul 11. Blood. 2006. PMID: 16835374 Free article.
NLRC4 gets out of control.
Khameneh HJ, Mortellaro A. Khameneh HJ, et al. Among authors: mortellaro a. Nat Genet. 2014 Oct;46(10):1048-9. doi: 10.1038/ng.3100. Nat Genet. 2014. PMID: 25257084
Genome-wide analysis of the genetic regulation of gene expression in human neutrophils.
Andiappan AK, Melchiotti R, Poh TY, Nah M, Puan KJ, Vigano E, Haase D, Yusof N, San Luis B, Lum J, Kumar D, Foo S, Zhuang L, Vasudev A, Irwanto A, Lee B, Nardin A, Liu H, Zhang F, Connolly J, Liu J, Mortellaro A, Wang Y, Poidinger M, Larbi A, Zolezzi F, Rotzschke O. Andiappan AK, et al. Among authors: mortellaro a. Nat Commun. 2015 Aug 10;6:7971. doi: 10.1038/ncomms8971. Nat Commun. 2015. PMID: 26259071 Free PMC article.
Targeting Glycolysis in Macrophages Confers Protection Against Pancreatic Ductal Adenocarcinoma.
Penny HL, Sieow JL, Gun SY, Lau MC, Lee B, Tan J, Phua C, Toh F, Nga Y, Yeap WH, Janela B, Kumar D, Chen H, Yeong J, Kenkel JA, Pang A, Lim D, Toh HC, Hon TLK, Johnson CI, Khameneh HJ, Mortellaro A, Engleman EG, Rotzschke O, Ginhoux F, Abastado JP, Chen J, Wong SC. Penny HL, et al. Among authors: mortellaro a. Int J Mol Sci. 2021 Jun 14;22(12):6350. doi: 10.3390/ijms22126350. Int J Mol Sci. 2021. PMID: 34198548 Free PMC article.
Lentiviral correction of enzymatic activity restrains macrophage inflammation in adenosine deaminase 2 deficiency.
Zoccolillo M, Brigida I, Barzaghi F, Scala S, Hernández RJ, Basso-Ricci L, Colantuoni M, Pettinato E, Sergi LS, Milardi G, Capasso P, Lombardo A, Gregori S, Sanvito F, Schena F, Cesaro S, Conti F, Pession A, Benedetti F, Gattorno M, Lee PY, Naldini L, Cicalese MP, Aiuti A, Mortellaro A. Zoccolillo M, et al. Among authors: mortellaro a. Blood Adv. 2021 Aug 24;5(16):3174-3187. doi: 10.1182/bloodadvances.2020003811. Blood Adv. 2021. PMID: 34424322 Free PMC article.
65 results