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Combined innate and adaptive immunotherapy overcomes resistance of immunologically cold syngeneic murine neuroblastoma to checkpoint inhibition.
Voeller J, Erbe AK, Slowinski J, Rasmussen K, Carlson PM, Hoefges A, VandenHeuvel S, Stuckwisch A, Wang X, Gillies SD, Patel RB, Farrel A, Rokita JL, Maris J, Hank JA, Morris ZS, Rakhmilevich AL, Sondel PM. Voeller J, et al. Among authors: morris zs. J Immunother Cancer. 2019 Dec 6;7(1):344. doi: 10.1186/s40425-019-0823-6. J Immunother Cancer. 2019. PMID: 31810498 Free PMC article.
In situ vaccination at a peripheral tumor site augments response against melanoma brain metastases.
Clark PA, Sriramaneni RN, Jin WJ, Jagodinsky JC, Bates AM, Jaquish AA, Anderson BR, Le T, Lubin JA, Chakravarty I, Arthur IS, Heinze CM, Guy EI, Kler J, Klar KA, Carlson PM, Kim KM, Kuo JS, Morris ZS. Clark PA, et al. Among authors: morris zs. J Immunother Cancer. 2020 Jul;8(2):e000809. doi: 10.1136/jitc-2020-000809. J Immunother Cancer. 2020. PMID: 32690669 Free PMC article.
Combination of radiation therapy, bempegaldesleukin, and checkpoint blockade eradicates advanced solid tumors and metastases in mice.
Pieper AA, Rakhmilevich AL, Spiegelman DV, Patel RB, Birstler J, Jin WJ, Carlson PM, Charych DH, Hank JA, Erbe AK, Overwijk WW, Morris ZS, Sondel PM. Pieper AA, et al. Among authors: morris zs. J Immunother Cancer. 2021 Jun;9(6):e002715. doi: 10.1136/jitc-2021-002715. J Immunother Cancer. 2021. PMID: 34172518 Free PMC article.
Local TLR4 stimulation augments in situ vaccination induced via local radiation and anti-CTLA-4 checkpoint blockade through induction of CD8 T-cell independent Th1 polarization.
Jagodinsky JC, Bates AM, Clark PA, Sriramaneni RN, Havighurst TC, Chakravarty I, Nystuen EJ, Kim K, Sondel PM, Jin WJ, Morris ZS. Jagodinsky JC, et al. Among authors: morris zs. J Immunother Cancer. 2022 Oct;10(10):e005103. doi: 10.1136/jitc-2022-005103. J Immunother Cancer. 2022. PMID: 36192087 Free PMC article.
Radiation to all macroscopic sites of tumor permits greater systemic antitumor response to in situ vaccination.
Carlson PM, Patel RB, Birstler J, Rodriquez M, Sun C, Erbe AK, Bates AM, Marsh I, Grudzinski J, Hernandez R, Pieper AA, Feils AS, Rakhmilevich AL, Weichert JP, Bednarz BP, Sondel PM, Morris ZS. Carlson PM, et al. Among authors: morris zs. J Immunother Cancer. 2023 Jan;11(1):e005463. doi: 10.1136/jitc-2022-005463. J Immunother Cancer. 2023. PMID: 36639155 Free PMC article.
Factors impacting the efficacy of the in-situ vaccine with CpG and OX40 agonist.
Pieper AA, Spiegelman DV, Felder MAR, Feils AS, Tsarovsky NW, Zaborek J, Morris ZS, Erbe AK, Rakhmilevich AL, Sondel PM. Pieper AA, et al. Among authors: morris zs. Cancer Immunol Immunother. 2023 Jul;72(7):2459-2471. doi: 10.1007/s00262-023-03433-3. Epub 2023 Apr 5. Cancer Immunol Immunother. 2023. PMID: 37016127 Free PMC article.
104 results