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SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4.
Tzelepis K, De Braekeleer E, Aspris D, Barbieri I, Vijayabaskar MS, Liu WH, Gozdecka M, Metzakopian E, Toop HD, Dudek M, Robson SC, Hermida-Prado F, Yang YH, Babaei-Jadidi R, Garyfallos DA, Ponstingl H, Dias JML, Gallipoli P, Seiler M, Buonamici S, Vick B, Bannister AJ, Rad R, Prinjha RK, Marioni JC, Huntly B, Batson J, Morris JC, Pina C, Bradley A, Jeremias I, Bates DO, Yusa K, Kouzarides T, Vassiliou GS. Tzelepis K, et al. Among authors: morris jc. Nat Commun. 2018 Dec 19;9(1):5378. doi: 10.1038/s41467-018-07620-0. Nat Commun. 2018. PMID: 30568163 Free PMC article.
Development of Potent, Selective SRPK1 Inhibitors as Potential Topical Therapeutics for Neovascular Eye Disease.
Batson J, Toop HD, Redondo C, Babaei-Jadidi R, Chaikuad A, Wearmouth SF, Gibbons B, Allen C, Tallant C, Zhang J, Du C, Hancox JC, Hawtrey T, Da Rocha J, Griffith R, Knapp S, Bates DO, Morris JC. Batson J, et al. Among authors: morris jc. ACS Chem Biol. 2017 Mar 17;12(3):825-832. doi: 10.1021/acschembio.6b01048. Epub 2017 Feb 6. ACS Chem Biol. 2017. PMID: 28135068 Free article.
Serine-arginine-rich protein kinase-1 inhibition for the treatment of diabetic retinopathy.
Malhi NK, Allen CL, Stewart E, Horton KL, Riu F, Batson J, Amoaku W, Morris JC, Arkill KP, Bates DO. Malhi NK, et al. Among authors: morris jc. Am J Physiol Heart Circ Physiol. 2022 Jun 1;322(6):H1014-H1027. doi: 10.1152/ajpheart.00001.2022. Epub 2022 Mar 18. Am J Physiol Heart Circ Physiol. 2022. PMID: 35302878 Free PMC article.
Pharmacology of Modulators of Alternative Splicing.
Bates DO, Morris JC, Oltean S, Donaldson LF. Bates DO, et al. Among authors: morris jc. Pharmacol Rev. 2017 Jan;69(1):63-79. doi: 10.1124/pr.115.011239. Pharmacol Rev. 2017. PMID: 28034912 Free PMC article. Review.
A fluorescent assay for ceramide synthase activity.
Kim HJ, Qiao Q, Toop HD, Morris JC, Don AS. Kim HJ, et al. Among authors: morris jc. J Lipid Res. 2012 Aug;53(8):1701-7. doi: 10.1194/jlr.D025627. Epub 2012 Jun 1. J Lipid Res. 2012. PMID: 22661289 Free PMC article.
A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism.
Turner N, Lim XY, Toop HD, Osborne B, Brandon AE, Taylor EN, Fiveash CE, Govindaraju H, Teo JD, McEwen HP, Couttas TA, Butler SM, Das A, Kowalski GM, Bruce CR, Hoehn KL, Fath T, Schmitz-Peiffer C, Cooney GJ, Montgomery MK, Morris JC, Don AS. Turner N, et al. Among authors: morris jc. Nat Commun. 2018 Aug 21;9(1):3165. doi: 10.1038/s41467-018-05613-7. Nat Commun. 2018. PMID: 30131496 Free PMC article.
Activation of protein phosphatase 2A in FLT3+ acute myeloid leukemia cells enhances the cytotoxicity of FLT3 tyrosine kinase inhibitors.
Smith AM, Dun MD, Lee EM, Harrison C, Kahl R, Flanagan H, Panicker N, Mashkani B, Don AS, Morris J, Toop H, Lock RB, Powell JA, Thomas D, Guthridge MA, Moore A, Ashman LK, Skelding KA, Enjeti A, Verrills NM. Smith AM, et al. Oncotarget. 2016 Jul 26;7(30):47465-47478. doi: 10.18632/oncotarget.10167. Oncotarget. 2016. PMID: 27329844 Free PMC article.
1,647 results