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Exploring biocompatible chemistry to create stapled and photoswitchable variants of the antimicrobial peptide aurein 1.2.
J Pept Sci. 2024 Apr;30(4):e3551. doi: 10.1002/psc.3551. Epub 2023 Nov 5.
J Pept Sci. 2024.
PMID: 37926859
Selective thiazoline peptide cyclisation compatible with mRNA display and efficient synthesis.
Liu M, Morewood R, Yoshisada R, Pascha MN, Hopstaken AJP, Tarcoveanu E, Poole DA 3rd, de Haan CAM, Nitsche C, Jongkees SAK.
Liu M, et al. Among authors: morewood r.
Chem Sci. 2023 Sep 8;14(38):10561-10569. doi: 10.1039/d3sc03117a. eCollection 2023 Oct 4.
Chem Sci. 2023.
PMID: 37799990
Free PMC article.
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Site-selective generation of lanthanoid binding sites on proteins using 4-fluoro-2,6-dicyanopyridine.
Mekkattu Tharayil S, Mahawaththa MC, Feintuch A, Maleckis A, Ullrich S, Morewood R, Maxwell MJ, Huber T, Nitsche C, Goldfarb D, Otting G.
Mekkattu Tharayil S, et al. Among authors: morewood r.
Magn Reson (Gott). 2022 Sep 13;3(2):169-182. doi: 10.5194/mr-3-169-2022. eCollection 2022.
Magn Reson (Gott). 2022.
PMID: 37904871
Free PMC article.
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Bioinspired peptide stapling generates stable enzyme inhibitors.
Morewood R, Nitsche C.
Morewood R, et al.
Chem Commun (Camb). 2022 Sep 27;58(77):10817-10820. doi: 10.1039/d2cc03510c.
Chem Commun (Camb). 2022.
PMID: 36069401
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Biocompatible and Selective Generation of Bicyclic Peptides.
Ullrich S, George J, Coram AE, Morewood R, Nitsche C.
Ullrich S, et al. Among authors: morewood r.
Angew Chem Int Ed Engl. 2022 Oct 24;61(43):e202208400. doi: 10.1002/anie.202208400. Epub 2022 Aug 22.
Angew Chem Int Ed Engl. 2022.
PMID: 35852030
Free PMC article.
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Challenges of short substrate analogues as SARS-CoV-2 main protease inhibitors.
Ullrich S, Sasi VM, Mahawaththa MC, Ekanayake KB, Morewood R, George J, Shuttleworth L, Zhang X, Whitefield C, Otting G, Jackson C, Nitsche C.
Ullrich S, et al. Among authors: morewood r.
Bioorg Med Chem Lett. 2021 Oct 15;50:128333. doi: 10.1016/j.bmcl.2021.128333. Epub 2021 Aug 19.
Bioorg Med Chem Lett. 2021.
PMID: 34418570
Free PMC article.
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A biocompatible stapling reaction for in situ generation of constrained peptides.
Morewood R, Nitsche C.
Morewood R, et al.
Chem Sci. 2020 Nov 4;12(2):669-674. doi: 10.1039/d0sc05125j.
Chem Sci. 2020.
PMID: 34163798
Free PMC article.
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2-Cyanoisonicotinamide Conjugation: A Facile Approach to Generate Potent Peptide Inhibitors of the Zika Virus Protease.
Patil NA, Quek JP, Schroeder B, Morewood R, Rademann J, Luo D, Nitsche C.
Patil NA, et al. Among authors: morewood r.
ACS Med Chem Lett. 2021 Mar 31;12(5):732-737. doi: 10.1021/acsmedchemlett.0c00657. eCollection 2021 May 13.
ACS Med Chem Lett. 2021.
PMID: 34055219
Free PMC article.
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