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SOX2 haploinsufficiency promotes impaired vision at advanced age.
Moreno-Cugnon L, Anasagasti A, Ezquerra-Inchausti M, Izeta A, de la Villa P, Ruiz-Ederra J, Matheu A. Moreno-Cugnon L, et al. Oncotarget. 2018 Nov 30;9(94):36684-36692. doi: 10.18632/oncotarget.26393. eCollection 2018 Nov 30. Oncotarget. 2018. PMID: 30613351 Free PMC article.
SOX2 expression diminishes with ageing in several tissues in mice and humans.
Carrasco-Garcia E, Moreno-Cugnon L, Garcia I, Borras C, Revuelta M, Izeta A, Lopez-Lluch G, de Pancorbo MM, Vergara I, Vina J, Matheu A. Carrasco-Garcia E, et al. Mech Ageing Dev. 2019 Jan;177:30-36. doi: 10.1016/j.mad.2018.03.008. Epub 2018 Mar 21. Mech Ageing Dev. 2019. PMID: 29574045
Increased Arf/p53 activity in stem cells, aging and cancer.
Carrasco-Garcia E, Moreno M, Moreno-Cugnon L, Matheu A. Carrasco-Garcia E, et al. Aging Cell. 2017 Apr;16(2):219-225. doi: 10.1111/acel.12574. Epub 2017 Jan 19. Aging Cell. 2017. PMID: 28101907 Free PMC article. Review.
Elevated p38MAPK activity promotes neural stem cell aging.
Moreno-Cugnon L, Arrizabalaga O, Llarena I, Matheu A. Moreno-Cugnon L, et al. Aging (Albany NY). 2020 Apr 3;12(7):6030-6036. doi: 10.18632/aging.102994. Epub 2020 Apr 3. Aging (Albany NY). 2020. PMID: 32243258 Free PMC article.
mTOR inhibition decreases SOX2-SOX9 mediated glioma stem cell activity and temozolomide resistance.
Garros-Regulez L, Aldaz P, Arrizabalaga O, Moncho-Amor V, Carrasco-Garcia E, Manterola L, Moreno-Cugnon L, Barrena C, Villanua J, Ruiz I, Pollard S, Lovell-Badge R, Sampron N, Garcia I, Matheu A. Garros-Regulez L, et al. Expert Opin Ther Targets. 2016;20(4):393-405. doi: 10.1517/14728222.2016.1151002. Expert Opin Ther Targets. 2016. PMID: 26878385 Free PMC article.
Targeting SOX2 as a Therapeutic Strategy in Glioblastoma.
Garros-Regulez L, Garcia I, Carrasco-Garcia E, Lantero A, Aldaz P, Moreno-Cugnon L, Arrizabalaga O, Undabeitia J, Torres-Bayona S, Villanua J, Ruiz I, Egaña L, Sampron N, Matheu A. Garros-Regulez L, et al. Front Oncol. 2016 Oct 24;6:222. doi: 10.3389/fonc.2016.00222. eCollection 2016. Front Oncol. 2016. PMID: 27822457 Free PMC article. Review.
Ischemic stroke in neonatal and adult astrocytes.
Revuelta M, Elicegui A, Moreno-Cugnon L, Bührer C, Matheu A, Schmitz T. Revuelta M, et al. Among authors: moreno cugnon l. Mech Ageing Dev. 2019 Oct;183:111147. doi: 10.1016/j.mad.2019.111147. Epub 2019 Sep 4. Mech Ageing Dev. 2019. PMID: 31493435 Review.
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