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The Multi-Kinase Inhibitor EC-70124 Is a Promising Candidate for the Treatment of FLT3-ITD-Positive Acute Myeloid Leukemia.
Lopez-Millan B, Costales P, Gutiérrez-Agüera F, Díaz de la Guardia R, Roca-Ho H, Vinyoles M, Rubio-Gayarre A, Safi R, Castaño J, Romecín PA, Ramírez-Orellana M, Anguita E, Jeremias I, Zamora L, Rodríguez-Manzaneque JC, Bueno C, Morís F, Menendez P. Lopez-Millan B, et al. Among authors: moris f. Cancers (Basel). 2022 Mar 21;14(6):1593. doi: 10.3390/cancers14061593. Cancers (Basel). 2022. PMID: 35326743 Free PMC article.
Inhibition of FLT3 and PIM Kinases by EC-70124 Exerts Potent Activity in Preclinical Models of Acute Myeloid Leukemia.
Puente-Moncada N, Costales P, Antolín I, Núñez LE, Oro P, Hermosilla MA, Pérez-Escuredo J, Ríos-Lombardía N, Sanchez-Sanchez AM, Luño E, Rodríguez C, Martín V, Morís F. Puente-Moncada N, et al. Among authors: moris f. Mol Cancer Ther. 2018 Mar;17(3):614-624. doi: 10.1158/1535-7163.MCT-17-0530. Epub 2018 Jan 16. Mol Cancer Ther. 2018. PMID: 29339551
The multikinase inhibitor EC-70124 synergistically increased the antitumor activity of doxorubicin in sarcomas.
Estupiñan O, Santos L, Rodriguez A, Fernandez-Nevado L, Costales P, Perez-Escuredo J, Hermosilla MA, Oro P, Rey V, Tornin J, Allonca E, Fernandez-Garcia MT, Alvarez-Fernandez C, Braña A, Astudillo A, Menendez ST, Moris F, Rodriguez R. Estupiñan O, et al. Among authors: moris f. Int J Cancer. 2019 Jul 1;145(1):254-266. doi: 10.1002/ijc.32081. Epub 2019 Jan 14. Int J Cancer. 2019. PMID: 30575954 Free article.
EC-70124, a Novel Glycosylated Indolocarbazole Multikinase Inhibitor, Reverts Tumorigenic and Stem Cell Properties in Prostate Cancer by Inhibiting STAT3 and NF-κB.
Civenni G, Longoni N, Costales P, Dallavalle C, García Inclán C, Albino D, Nuñez LE, Morís F, Carbone GM, Catapano CV. Civenni G, et al. Among authors: moris f. Mol Cancer Ther. 2016 May;15(5):806-18. doi: 10.1158/1535-7163.MCT-15-0791. Epub 2016 Jan 29. Mol Cancer Ther. 2016. PMID: 26826115
Factors Secreted by Cancer-Associated Fibroblasts that Sustain Cancer Stem Properties in Head and Neck Squamous Carcinoma Cells as Potential Therapeutic Targets.
Álvarez-Teijeiro S, García-Inclán C, Villaronga MÁ, Casado P, Hermida-Prado F, Granda-Díaz R, Rodrigo JP, Calvo F, Del-Río-Ibisate N, Gandarillas A, Morís F, Hermsen M, Cutillas P, García-Pedrero JM. Álvarez-Teijeiro S, et al. Among authors: moris f. Cancers (Basel). 2018 Sep 17;10(9):334. doi: 10.3390/cancers10090334. Cancers (Basel). 2018. PMID: 30227608 Free PMC article.
Genetic Engineering in Combination with Semi-Synthesis Leads to a New Route for Gram-Scale Production of the Immunosuppressive Natural Product Brasilicardin A.
Botas A, Eitel M, Schwarz PN, Buchmann A, Costales P, Núñez LE, Cortés J, Morís F, Krawiec M, Wolański M, Gust B, Rodriguez M, Fischer WN, Jandeleit B, Zakrzewska-Czerwińska J, Wohlleben W, Stegmann E, Koch P, Méndez C, Gross H. Botas A, et al. Among authors: moris f. Angew Chem Int Ed Engl. 2021 Jun 7;60(24):13536-13541. doi: 10.1002/anie.202015852. Epub 2021 May 1. Angew Chem Int Ed Engl. 2021. PMID: 33768597 Free PMC article.
Abrogation of stemness in osteosarcoma by the mithramycin analog EC-8042 is mediated by its ability to inhibit NOTCH-1 signaling.
Estupiñán Ó, Rey V, Tornín J, Murillo D, Gallego B, Huergo C, Blanco-Lorenzo V, Victoria González M, Rodríguez A, Moris F, González J, Ayllón V, Ramos-Mejía V, Bigas A, Rodríguez R. Estupiñán Ó, et al. Among authors: moris f. Biomed Pharmacother. 2023 Jun;162:114627. doi: 10.1016/j.biopha.2023.114627. Epub 2023 Apr 3. Biomed Pharmacother. 2023. PMID: 37018985 Free article.
55 results