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A kinase-cGAS cascade to synthesize a therapeutic STING activator.
McIntosh JA, Liu Z, Andresen BM, Marzijarani NS, Moore JC, Marshall NM, Borra-Garske M, Obligacion JV, Fier PS, Peng F, Forstater JH, Winston MS, An C, Chang W, Lim J, Huffman MA, Miller SP, Tsay FR, Altman MD, Lesburg CA, Steinhuebel D, Trotter BW, Cumming JN, Northrup A, Bu X, Mann BF, Biba M, Hiraga K, Murphy GS, Kolev JN, Makarewicz A, Pan W, Farasat I, Bade RS, Stone K, Duan D, Alvizo O, Adpressa D, Guetschow E, Hoyt E, Regalado EL, Castro S, Rivera N, Smith JP, Wang F, Crespo A, Verma D, Axnanda S, Dance ZEX, Devine PN, Tschaen D, Canada KA, Bulger PG, Sherry BD, Truppo MD, Ruck RT, Campeau LC, Bennett DJ, Humphrey GR, Campos KR, Maddess ML. McIntosh JA, et al. Among authors: moore jc. Nature. 2022 Mar;603(7901):439-444. doi: 10.1038/s41586-022-04422-9. Epub 2022 Mar 16. Nature. 2022. PMID: 35296845
Advances in the enzymatic reduction of ketones.
Moore JC, Pollard DJ, Kosjek B, Devine PN. Moore JC, et al. Acc Chem Res. 2007 Dec;40(12):1412-9. doi: 10.1021/ar700167a. Epub 2007 Dec 4. Acc Chem Res. 2007. PMID: 18052114 Review.
Overcoming "speed limits" in high throughput chromatographic analysis.
Zawatzky K, Barhate CL, Regalado EL, Mann BF, Marshall N, Moore JC, Welch CJ. Zawatzky K, et al. Among authors: moore jc. J Chromatogr A. 2017 May 26;1499:211-216. doi: 10.1016/j.chroma.2017.04.002. Epub 2017 Apr 4. J Chromatogr A. 2017. PMID: 28416217
Design of an in vitro biocatalytic cascade for the manufacture of islatravir.
Huffman MA, Fryszkowska A, Alvizo O, Borra-Garske M, Campos KR, Canada KA, Devine PN, Duan D, Forstater JH, Grosser ST, Halsey HM, Hughes GJ, Jo J, Joyce LA, Kolev JN, Liang J, Maloney KM, Mann BF, Marshall NM, McLaughlin M, Moore JC, Murphy GS, Nawrat CC, Nazor J, Novick S, Patel NR, Rodriguez-Granillo A, Robaire SA, Sherer EC, Truppo MD, Whittaker AM, Verma D, Xiao L, Xu Y, Yang H. Huffman MA, et al. Among authors: moore jc. Science. 2019 Dec 6;366(6470):1255-1259. doi: 10.1126/science.aay8484. Science. 2019. PMID: 31806816
Diverse Catalytic Reactions for the Stereoselective Synthesis of Cyclic Dinucleotide MK-1454.
Benkovics T, Peng F, Phillips EM, An C, Bade RS, Chung CK, Dance ZEX, Fier PS, Forstater JH, Liu Z, Liu Z, Maligres PE, Marshall NM, Salehi Marzijarani N, McIntosh JA, Miller SP, Moore JC, Neel AJ, Obligacion JV, Pan W, Pirnot MT, Poirier M, Reibarkh M, Sherry BD, Song ZJ, Tan L, Turnbull BWH, Verma D, Waldman JH, Wang L, Wang T, Winston MS, Xu F. Benkovics T, et al. Among authors: moore jc. J Am Chem Soc. 2022 Apr 6;144(13):5855-5863. doi: 10.1021/jacs.1c12106. Epub 2022 Mar 25. J Am Chem Soc. 2022. PMID: 35333525
446 results