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CNX-012-570, a direct AMPK activator provides strong glycemic and lipid control along with significant reduction in body weight; studies from both diet-induced obese mice and db/db mice models.
Cardiovasc Diabetol. 2014 Jan 25;13:27. doi: 10.1186/1475-2840-13-27.
Cardiovasc Diabetol. 2014.
PMID: 24460834
Free PMC article.
A novel 11β-hydroxysteroid dehydrogenase type1 inhibitor CNX-010-49 improves hyperglycemia, lipid profile and reduces body weight in diet induced obese C57B6/J mice with a potential to provide cardio protective benefits.
Anil TM, Dandu A, Harsha K, Singh J, Shree N, Kumar VS, Lakshmi MN, Sunil V, Harish C, Balamurali GV, Naveen Kumar BS, Gopala AS, Pratibha S, Sadasivuni M, Anup MO, Moolemath Y, Venkataranganna MV, Jagannath MR, Somesh BP.
Anil TM, et al. Among authors: moolemath y.
BMC Pharmacol Toxicol. 2014 Aug 7;15:43. doi: 10.1186/2050-6511-15-43.
BMC Pharmacol Toxicol. 2014.
PMID: 25098735
Free PMC article.
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CNX-013-B2, a unique pan tissue acting rexinoid, modulates several nuclear receptors and controls multiple risk factors of the metabolic syndrome without risk of hypertriglyceridemia, hepatomegaly and body weight gain in animal models.
Sadasivuni MK, Reddy BM, Singh J, Anup MO, Sunil V, Lakshmi MN, Yogeshwari S, Chacko SK, Pooja TL, Dandu A, Harish C, Gopala AS, Pratibha S, Naveenkumar BS, Pallavi PM, Verma MK, Moolemath Y, Somesh BP, Venkataranganna MV, Jagannath MR.
Sadasivuni MK, et al. Among authors: moolemath y.
Diabetol Metab Syndr. 2014 Aug 12;6(1):83. doi: 10.1186/1758-5996-6-83. eCollection 2014.
Diabetol Metab Syndr. 2014.
PMID: 25143786
Free PMC article.
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CNX-011-67, a novel GPR40 agonist, enhances glucose responsiveness, insulin secretion and islet insulin content in n-STZ rats and in islets from type 2 diabetic patients.
Sunil V, Verma MK, Oommen AM, Sadasivuni M, Singh J, Vijayraghav DN, Chandravanshi B, Shetty J, Biswas S, Dandu A, Moolemath Y, Venkataranganna MV, Somesh BP, Jagannath MR.
Sunil V, et al. Among authors: moolemath y.
BMC Pharmacol Toxicol. 2014 Mar 25;15:19. doi: 10.1186/2050-6511-15-19.
BMC Pharmacol Toxicol. 2014.
PMID: 24666736
Free PMC article.
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Treatment with CNX-011-67, a novel GPR40 agonist, delays onset and progression of diabetes and improves beta cell preservation and function in male ZDF rats.
Gowda N, Dandu A, Singh J, Biswas S, Raghav V, Lakshmi MN, Shilpa PC, Sunil V, Reddy A, Sadasivuni M, Aparna K, Verma MK, Moolemath Y, Anup MO, Venkataranganna MV, Somesh BP, Jagannath MR.
Gowda N, et al. Among authors: moolemath y.
BMC Pharmacol Toxicol. 2013 May 21;14:28. doi: 10.1186/2050-6511-14-28.
BMC Pharmacol Toxicol. 2013.
PMID: 23692921
Free PMC article.
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The beneficial role of Naringin- a citrus bioflavonoid, against oxidative stress-induced neurobehavioral disorders and cognitive dysfunction in rodents: A systematic review and meta-analysis.
Viswanatha GL, Shylaja H, Moolemath Y.
Viswanatha GL, et al. Among authors: moolemath y.
Biomed Pharmacother. 2017 Oct;94:909-929. doi: 10.1016/j.biopha.2017.07.072. Epub 2017 Aug 16.
Biomed Pharmacother. 2017.
PMID: 28810519
Review.
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Fast food diet with CCl4 micro-dose induced hepatic-fibrosis--a novel animal model.
Chheda TK, Shivakumar P, Sadasivan SK, Chanderasekharan H, Moolemath Y, Oommen AM, Madanahalli JR, Marikunte VV.
Chheda TK, et al. Among authors: moolemath y.
BMC Gastroenterol. 2014 May 10;14:89. doi: 10.1186/1471-230X-14-89.
BMC Gastroenterol. 2014.
PMID: 24884574
Free PMC article.
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