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A substrate-specific mTORC1 pathway underlies Birt-Hogg-Dubé syndrome.
Napolitano G, Di Malta C, Esposito A, de Araujo MEG, Pece S, Bertalot G, Matarese M, Benedetti V, Zampelli A, Stasyk T, Siciliano D, Venuta A, Cesana M, Vilardo C, Nusco E, Monfregola J, Calcagnì A, Di Fiore PP, Huber LA, Ballabio A. Napolitano G, et al. Among authors: monfregola j. Nature. 2020 Sep;585(7826):597-602. doi: 10.1038/s41586-020-2444-0. Epub 2020 Jul 1. Nature. 2020. PMID: 32612235 Free PMC article.
NESCA: a new NEMO/IKKgamma and TRAF6 interacting protein.
Napolitano G, Mirra S, Monfregola J, Lavorgna A, Leonardi A, Ursini MV. Napolitano G, et al. Among authors: monfregola j. J Cell Physiol. 2009 Aug;220(2):410-7. doi: 10.1002/jcp.21782. J Cell Physiol. 2009. PMID: 19365808
Transcriptional activation of RagD GTPase controls mTORC1 and promotes cancer growth.
Di Malta C, Siciliano D, Calcagni A, Monfregola J, Punzi S, Pastore N, Eastes AN, Davis O, De Cegli R, Zampelli A, Di Giovannantonio LG, Nusco E, Platt N, Guida A, Ogmundsdottir MH, Lanfrancone L, Perera RM, Zoncu R, Pelicci PG, Settembre C, Ballabio A. Di Malta C, et al. Among authors: monfregola j. Science. 2017 Jun 16;356(6343):1188-1192. doi: 10.1126/science.aag2553. Science. 2017. PMID: 28619945 Free PMC article.
mTORC1 hyperactivation arrests bone growth in lysosomal storage disorders by suppressing autophagy.
Bartolomeo R, Cinque L, De Leonibus C, Forrester A, Salzano AC, Monfregola J, De Gennaro E, Nusco E, Azario I, Lanzara C, Serafini M, Levine B, Ballabio A, Settembre C. Bartolomeo R, et al. Among authors: monfregola j. J Clin Invest. 2017 Oct 2;127(10):3717-3729. doi: 10.1172/JCI94130. Epub 2017 Sep 5. J Clin Invest. 2017. PMID: 28872463 Free PMC article.
mTOR-dependent phosphorylation controls TFEB nuclear export.
Napolitano G, Esposito A, Choi H, Matarese M, Benedetti V, Di Malta C, Monfregola J, Medina DL, Lippincott-Schwartz J, Ballabio A. Napolitano G, et al. Among authors: monfregola j. Nat Commun. 2018 Aug 17;9(1):3312. doi: 10.1038/s41467-018-05862-6. Nat Commun. 2018. PMID: 30120233 Free PMC article.
29 results