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Dot1 promotes H2B ubiquitination by a methyltransferase-independent mechanism.
van Welsem T, Korthout T, Ekkebus R, Morais D, Molenaar TM, van Harten K, Poramba-Liyanage DW, Sun SM, Lenstra TL, Srivas R, Ideker T, Holstege FCP, van Attikum H, El Oualid F, Ovaa H, Stulemeijer IJE, Vlaming H, van Leeuwen F. van Welsem T, et al. Among authors: molenaar tm. Nucleic Acids Res. 2018 Nov 30;46(21):11251-11261. doi: 10.1093/nar/gky801. Nucleic Acids Res. 2018. PMID: 30203048 Free PMC article.
Conserved crosstalk between histone deacetylation and H3K79 methylation generates DOT1L-dose dependency in HDAC1-deficient thymic lymphoma.
Vlaming H, McLean CM, Korthout T, Alemdehy MF, Hendriks S, Lancini C, Palit S, Klarenbeek S, Kwesi-Maliepaard EM, Molenaar TM, Hoekman L, Schmidlin TT, Altelaar AM, van Welsem T, Dannenberg JH, Jacobs H, van Leeuwen F. Vlaming H, et al. Among authors: molenaar tm. EMBO J. 2019 Jul 15;38(14):e101564. doi: 10.15252/embj.2019101564. Epub 2019 Jun 17. EMBO J. 2019. PMID: 31304633 Free PMC article.
The histone methyltransferase SETD2 negatively regulates cell size.
Molenaar TM, Malik M, Silva J, Liu NQ, Haarhuis JHI, Ambrosi C, Kwesi-Maliepaard EM, van Welsem T, Baubec T, Faller WJ, van Leeuwen F. Molenaar TM, et al. J Cell Sci. 2022 Oct 1;135(19):jcs259856. doi: 10.1242/jcs.259856. Epub 2022 Oct 6. J Cell Sci. 2022. PMID: 36052643 Free PMC article.
CRISPR screens in sister chromatid cohesion defective cells reveal PAXIP1-PAGR1 as regulator of chromatin association of cohesin.
van Schie JJM, de Lint K, Molenaar TM, Moronta Gines M, Balk JA, Rooimans MA, Roohollahi K, Pai GM, Borghuis L, Ramadhin AR, Corazza F, Dorsman JC, Wendt KS, Wolthuis RMF, de Lange J. van Schie JJM, et al. Among authors: molenaar tm. Nucleic Acids Res. 2023 Oct 13;51(18):9594-9609. doi: 10.1093/nar/gkad756. Nucleic Acids Res. 2023. PMID: 37702151 Free PMC article.