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MLKL Requires the Inositol Phosphate Code to Execute Necroptosis.
Dovey CM, Diep J, Clarke BP, Hale AT, McNamara DE, Guo H, Brown NW Jr, Cao JY, Grace CR, Gough PJ, Bertin J, Dixon SJ, Fiedler D, Mocarski ES, Kaiser WJ, Moldoveanu T, York JD, Carette JE. Dovey CM, et al. Among authors: moldoveanu t. Mol Cell. 2018 Jun 7;70(5):936-948.e7. doi: 10.1016/j.molcel.2018.05.010. Epub 2018 Jun 7. Mol Cell. 2018. PMID: 29883610 Free PMC article.
Direct Activation of Human MLKL by a Select Repertoire of Inositol Phosphate Metabolites.
McNamara DE, Dovey CM, Hale AT, Quarato G, Grace CR, Guibao CD, Diep J, Nourse A, Cai CR, Wu H, Kalathur RC, Green DR, York JD, Carette JE, Moldoveanu T. McNamara DE, et al. Among authors: moldoveanu t. Cell Chem Biol. 2019 Jun 20;26(6):863-877.e7. doi: 10.1016/j.chembiol.2019.03.010. Epub 2019 Apr 25. Cell Chem Biol. 2019. PMID: 31031142 Free PMC article.
Metabolic activation of CaMKII by coenzyme A.
McCoy F, Darbandi R, Lee HC, Bharatham K, Moldoveanu T, Grace CR, Dodd K, Lin W, Chen SI, Tangallapally RP, Kurokawa M, Lee RE, Shelat AA, Chen T, Green DR, Harris RA, Lin SH, Fissore RA, Colbran RJ, Nutt LK. McCoy F, et al. Among authors: moldoveanu t. Mol Cell. 2013 Nov 7;52(3):325-39. doi: 10.1016/j.molcel.2013.08.043. Epub 2013 Oct 3. Mol Cell. 2013. PMID: 24095281 Free PMC article.
BID-induced structural changes in BAK promote apoptosis.
Moldoveanu T, Grace CR, Llambi F, Nourse A, Fitzgerald P, Gehring K, Kriwacki RW, Green DR. Moldoveanu T, et al. Nat Struct Mol Biol. 2013 May;20(5):589-97. doi: 10.1038/nsmb.2563. Epub 2013 Apr 21. Nat Struct Mol Biol. 2013. PMID: 23604079 Free PMC article.
Structural basis of BAK activation in mitochondrial apoptosis initiation.
Singh G, Guibao CD, Seetharaman J, Aggarwal A, Grace CR, McNamara DE, Vaithiyalingam S, Waddell MB, Moldoveanu T. Singh G, et al. Among authors: moldoveanu t. Nat Commun. 2022 Jan 11;13(1):250. doi: 10.1038/s41467-021-27851-y. Nat Commun. 2022. PMID: 35017502 Free PMC article.
Small molecule SJ572946 activates BAK to initiate apoptosis.
Sekar G, Singh G, Qin X, Guibao CD, Schwam B, Inde Z, Grace CR, Zhang W, Slavish PJ, Lin W, Chen T, Lee RE, Rankovic Z, Sarosiek K, Moldoveanu T. Sekar G, et al. Among authors: moldoveanu t. iScience. 2022 Sep 6;25(10):105064. doi: 10.1016/j.isci.2022.105064. eCollection 2022 Oct 21. iScience. 2022. PMID: 36147946 Free PMC article.
44 results