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The BDNF Val68Met polymorphism causes a sex specific alcohol preference over social interaction and also acute tolerance to the anxiolytic effects of alcohol, a phenotype driven by malfunction of BDNF in the ventral hippocampus of male mice.
Moffat JJ, Sakhai SA, Hoisington ZW, Ehinger Y, Ron D. Moffat JJ, et al. Psychopharmacology (Berl). 2023 Feb;240(2):303-317. doi: 10.1007/s00213-022-06305-3. Epub 2023 Jan 9. Psychopharmacology (Berl). 2023. PMID: 36622381 Free PMC article.
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