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N-terminal acetylation shields proteins from degradation and promotes age-dependent motility and longevity.
Varland S, Silva RD, Kjosås I, Faustino A, Bogaert A, Billmann M, Boukhatmi H, Kellen B, Costanzo M, Drazic A, Osberg C, Chan K, Zhang X, Tong AHY, Andreazza S, Lee JJ, Nedyalkova L, Ušaj M, Whitworth AJ, Andrews BJ, Moffat J, Myers CL, Gevaert K, Boone C, Martinho RG, Arnesen T. Varland S, et al. Among authors: moffat j. Nat Commun. 2023 Oct 27;14(1):6774. doi: 10.1038/s41467-023-42342-y. Nat Commun. 2023. PMID: 37891180 Free PMC article.
Survival-based CRISPR genetic screens across a panel of permissive cell lines identify common and cell-specific SARS-CoV-2 host factors.
Chan K, Farias AG, Lee H, Guvenc F, Mero P, Brown KR, Ward H, Billmann M, Aulakh K, Astori A, Haider S, Marcon E, Braunschweig U, Pu S, Habsid A, Yan Tong AH, Christie-Holmes N, Budylowski P, Ghalami A, Mubareka S, Maguire F, Banerjee A, Mossman KL, Greenblatt J, Gray-Owen SD, Raught B, Blencowe BJ, Taipale M, Myers C, Moffat J. Chan K, et al. Among authors: moffat j. Heliyon. 2023 Jan;9(1):e12744. doi: 10.1016/j.heliyon.2022.e12744. Epub 2022 Dec 30. Heliyon. 2023. PMID: 36597481 Free PMC article.
Reproducibility metrics for context-specific CRISPR screens.
Billmann M, Ward HN, Aregger M, Costanzo M, Andrews BJ, Boone C, Moffat J, Myers CL. Billmann M, et al. Among authors: moffat j. Cell Syst. 2023 May 17;14(5):418-422.e2. doi: 10.1016/j.cels.2023.04.003. Cell Syst. 2023. PMID: 37201508
Identification of acquired Notch3 dependency in metastatic Head and Neck Cancer.
Kondratyev M, Pesic A, Ketela T, Stickle N, Beswick C, Shalev Z, Marastoni S, Samadian S, Dvorkin-Gheva A, Sayad A, Bashkurov M, Boasquevisque P, Datti A, Pugh TJ, Virtanen C, Moffat J, Grénman RA, Koritzinsky M, Wouters BG. Kondratyev M, et al. Among authors: moffat j. Commun Biol. 2023 May 18;6(1):538. doi: 10.1038/s42003-023-04828-9. Commun Biol. 2023. PMID: 37202533 Free PMC article.
Synergistic hyperactivation of both mTORC1 and mTORC2 underlies the neural abnormalities of PTEN-deficient human neurons and cortical organoids.
Dhaliwal NK, Weng OY, Dong X, Bhattacharya A, Ahmed M, Nishimura H, Choi WWY, Aggarwal A, Luikart BW, Shu Q, Li X, Wilson MD, Moffat J, Wang LY, Muffat J, Li Y. Dhaliwal NK, et al. Among authors: moffat j. Cell Rep. 2024 May 2;43(5):114173. doi: 10.1016/j.celrep.2024.114173. Online ahead of print. Cell Rep. 2024. PMID: 38700984 Free article.
Synthesis of LAVR-289, a new [(Z)-3-(acetoxymethyl)-4-(2,4-diaminopyrimidin-6-yl)oxy-but-2-enyl]phosphonic acid prodrug with pronounced antiviral activity against DNA viruses.
Bessières M, Roy V, Abuduani T, Favetta P, Snoeck R, Andrei G, Moffat J, Gallardo F, Agrofoglio LA. Bessières M, et al. Among authors: moffat j. Eur J Med Chem. 2024 May 5;271:116412. doi: 10.1016/j.ejmech.2024.116412. Epub 2024 Apr 15. Eur J Med Chem. 2024. PMID: 38643669 Free article.
Salmonella exploits membrane reservoirs for invasion of host cells.
Zhu H, Sydor AM, Boddy KC, Coyaud E, Laurent EMN, Au A, Tan JMJ, Yan BR, Moffat J, Muise AM, Yip CM, Grinstein S, Raught B, Brumell JH. Zhu H, et al. Among authors: moffat j. Nat Commun. 2024 Apr 10;15(1):3120. doi: 10.1038/s41467-024-47183-x. Nat Commun. 2024. PMID: 38600106 Free PMC article.
467 results