Mochly-Rosen D - Search Results

1

Paired SARS-CoV-2 spike protein mutations observed during ongoing SARS-CoV-2 viral transfer from humans to minks and back to humans.

Burkholz S, Pokhrel S, Kraemer BR, Mochly-Rosen D, Carback RT 3rd, Hodge T, Harris P, Ciotlos S, Wang L, Herst CV, Rubsamen R. Burkholz S, et al. Infect Genet Evol. 2021 Sep;93:104897. doi: 10.1016/j.meegid.2021.104897. Epub 2021 May 7. Infect Genet Evol. 2021. PMID: 33971305 Free PMC article.

2

Increased elastase sensitivity and decreased intramolecular interactions in the more transmissible 501Y.V1 and 501Y.V2 SARS-CoV-2 variants' spike protein-an in silico analysis.

Pokhrel S, Kraemer BR, Lee L, Samardzic K, Mochly-Rosen D. Pokhrel S, et al. PLoS One. 2021 May 26;16(5):e0251426. doi: 10.1371/journal.pone.0251426. eCollection 2021. PLoS One. 2021. PMID: 34038453 Free PMC article.

3

Natural variants in SARS-CoV-2 Spike protein pinpoint structural and functional hotspots with implications for prophylaxis and therapeutic strategies.

Pokhrel S, Kraemer BR, Burkholz S, Mochly-Rosen D. Pokhrel S, et al. Sci Rep. 2021 Jun 23;11(1):13120. doi: 10.1038/s41598-021-92641-x. Sci Rep. 2021. PMID: 34162970 Free PMC article.

4

Annotation of 1350 Common Genetic Variants of the 19 ALDH Multigene Family from Global Human Genome Aggregation Database (gnomAD).

Chen CH, Kraemer BR, Lee L, Mochly-Rosen D. Chen CH, et al. Biomolecules. 2021 Sep 29;11(10):1423. doi: 10.3390/biom11101423. Biomolecules. 2021. PMID: 34680056 Free PMC article.

5

Egg-Derived Anti-SARS-CoV-2 Immunoglobulin Y (IgY) With Broad Variant Activity as Intranasal Prophylaxis Against COVID-19.

Frumkin LR, Lucas M, Scribner CL, Ortega-Heinly N, Rogers J, Yin G, Hallam TJ, Yam A, Bedard K, Begley R, Cohen CA, Badger CV, Abbasi SA, Dye JM, McMillan B, Wallach M, Bricker TL, Joshi A, Boon ACM, Pokhrel S, Kraemer BR, Lee L, Kargotich S, Agochiya M, John TS, Mochly-Rosen D. Frumkin LR, et al. Front Immunol. 2022 Jun 1;13:899617. doi: 10.3389/fimmu.2022.899617. eCollection 2022. Front Immunol. 2022. PMID: 35720389 Free PMC article. Clinical Trial.

6

ALDH2 variance in disease and populations.

Chen CH, Kraemer BR, Mochly-Rosen D. Chen CH, et al. Dis Model Mech. 2022 Jun 1;15(6):dmm049601. doi: 10.1242/dmm.049601. Epub 2022 Jun 24. Dis Model Mech. 2022. PMID: 35749303 Free PMC article.

7

Analysis of well-annotated next-generation sequencing data reveals increasing cases of SARS-CoV-2 reinfection with Omicron.

Burkholz S, Rubsamen M, Blankenberg L, Carback RT 3rd, Mochly-Rosen D, Harris PE. Burkholz S, et al. Commun Biol. 2023 Mar 18;6(1):288. doi: 10.1038/s42003-023-04687-4. Commun Biol. 2023. PMID: 36934204 Free PMC article.

8

Targeting an allosteric site in dynamin-related protein 1 to inhibit Fis1-mediated mitochondrial dysfunction.

Rios L, Pokhrel S, Li SJ, Heo G, Haileselassie B, Mochly-Rosen D. Rios L, et al. Nat Commun. 2023 Jul 19;14(1):4356. doi: 10.1038/s41467-023-40043-0. Nat Commun. 2023. PMID: 37468472 Free PMC article.

9

SGLT2 inhibitor ameliorates endothelial dysfunction associated with the common ALDH2 alcohol flushing variant.

Guo H, Yu X, Liu Y, Paik DT, Justesen JM, Chandy M, Jahng JWS, Zhang T, Wu W, Rwere F, Zhao SR, Pokhrel S, Shivnaraine RV, Mukherjee S, Simon DJ, Manhas A, Zhang A, Chen CH, Rivas MA, Gross ER, Mochly-Rosen D, Wu JC. Guo H, et al. Sci Transl Med. 2023 Jan 25;15(680):eabp9952. doi: 10.1126/scitranslmed.abp9952. Epub 2023 Jan 25. Sci Transl Med. 2023. PMID: 36696485 Free PMC article.

10

The many hats of protein kinase Cδ: one enzyme with many functions.

Qvit N, Mochly-Rosen D. Qvit N, et al. Biochem Soc Trans. 2014 Dec;42(6):1529-33. doi: 10.1042/BST20140189. Biochem Soc Trans. 2014. PMID: 25399565 Free PMC article.

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