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Sizzled is unique among secreted frizzled-related proteins for its ability to specifically inhibit bone morphogenetic protein-1 (BMP-1)/tolloid-like proteinases.
Bijakowski C, Vadon-Le Goff S, Delolme F, Bourhis JM, Lécorché P, Ruggiero F, Becker-Pauly C, Yiallouros I, Stöcker W, Dive V, Hulmes DJ, Moali C. Bijakowski C, et al. Among authors: moali c. J Biol Chem. 2012 Sep 28;287(40):33581-93. doi: 10.1074/jbc.M112.380816. Epub 2012 Jul 23. J Biol Chem. 2012. PMID: 22825851 Free PMC article.
Production and crystallization of the C-propeptide trimer from human procollagen III.
Bourhis JM, Mariano N, Zhao Y, Walter TS, El Omari K, Delolme F, Moali C, Hulmes DJ, Aghajari N. Bourhis JM, et al. Among authors: moali c. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Oct 1;68(Pt 10):1209-13. doi: 10.1107/S1744309112035294. Epub 2012 Sep 26. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012. PMID: 23027749 Free PMC article.
Proteolytic control of TGF-β co-receptor activity by BMP-1/tolloid-like proteases revealed by quantitative iTRAQ proteomics.
Delolme F, Anastasi C, Alcaraz LB, Mendoza V, Vadon-Le Goff S, Talantikite M, Capomaccio R, Mevaere J, Fortin L, Mazzocut D, Damour O, Zanella-Cléon I, Hulmes DJ, Overall CM, Valcourt U, Lopez-Casillas F, Moali C. Delolme F, et al. Among authors: moali c. Cell Mol Life Sci. 2015 Mar;72(5):1009-27. doi: 10.1007/s00018-014-1733-x. Epub 2014 Sep 27. Cell Mol Life Sci. 2015. PMID: 25260970
Structural basis of homo- and heterotrimerization of collagen I.
Sharma U, Carrique L, Vadon-Le Goff S, Mariano N, Georges RN, Delolme F, Koivunen P, Myllyharju J, Moali C, Aghajari N, Hulmes DJ. Sharma U, et al. Among authors: moali c. Nat Commun. 2017 Mar 10;8:14671. doi: 10.1038/ncomms14671. Nat Commun. 2017. PMID: 28281531 Free PMC article.
BMP-1 disrupts cell adhesion and enhances TGF-β activation through cleavage of the matricellular protein thrombospondin-1.
Anastasi C, Rousselle P, Talantikite M, Tessier A, Cluzel C, Bachmann A, Mariano N, Dussoyer M, Alcaraz LB, Fortin L, Aubert A, Delolme F, El Kholti N, Armengaud J, Fournié P, Auxenfans C, Valcourt U, Goff SV, Moali C. Anastasi C, et al. Among authors: moali c. Sci Signal. 2020 Jul 7;13(639):eaba3880. doi: 10.1126/scisignal.aba3880. Sci Signal. 2020. PMID: 32636307
A 9-kDa matricellular SPARC fragment released by cathepsin D exhibits pro-tumor activity in the triple-negative breast cancer microenvironment.
Alcaraz LB, Mallavialle A, David T, Derocq D, Delolme F, Dieryckx C, Mollevi C, Boissière-Michot F, Simony-Lafontaine J, Du Manoir S, Huesgen PF, Overall CM, Tartare-Deckert S, Jacot W, Chardès T, Guiu S, Roger P, Reinheckel T, Moali C, Liaudet-Coopman E. Alcaraz LB, et al. Among authors: moali c. Theranostics. 2021 Apr 15;11(13):6173-6192. doi: 10.7150/thno.58254. eCollection 2021. Theranostics. 2021. PMID: 33995652 Free PMC article.
Determination of the substrate repertoire of ADAMTS2, 3, and 14 significantly broadens their functions and identifies extracellular matrix organization and TGF-β signaling as primary targets.
Bekhouche M, Leduc C, Dupont L, Janssen L, Delolme F, Vadon-Le Goff S, Smargiasso N, Baiwir D, Mazzucchelli G, Zanella-Cleon I, Dubail J, De Pauw E, Nusgens B, Hulmes DJ, Moali C, Colige A. Bekhouche M, et al. Among authors: moali c. FASEB J. 2016 May;30(5):1741-56. doi: 10.1096/fj.15-279869. Epub 2016 Jan 6. FASEB J. 2016. PMID: 26740262 Free article.
This work shows that the activities of the pNPs extend far beyond the classically reported processing of the aminopropeptide of fibrillar collagens and that they should now be considered as multilevel regulators of matrix deposition and remodeling.-Bekhouche, M., Leduc, C. …
This work shows that the activities of the pNPs extend far beyond the classically reported processing of the aminopropeptide of fibrillar co …
46 results