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Page 1
Sortilin enhances fibrosis and calcification in aortic valve disease by inducing interstitial cell heterogeneity.
Iqbal F, Schlotter F, Becker-Greene D, Lupieri A, Goettsch C, Hutcheson JD, Rogers MA, Itoh S, Halu A, Lee LH, Blaser MC, Mlynarchik AK, Hagita S, Kuraoka S, Chen HY, Engert JC, Passos LSA, Jha PK, Osborn EA, Jaffer FA, Body SC, Robson SC, Thanassoulis G, Aikawa M, Singh SA, Sonawane AR, Aikawa E. Iqbal F, et al. Among authors: mlynarchik ak. Eur Heart J. 2023 Mar 7;44(10):885-898. doi: 10.1093/eurheartj/ehac818. Eur Heart J. 2023. PMID: 36660854 Free PMC article.
A Novel Spectral Annotation Strategy Streamlines Reporting of Mono-ADP-ribosylated Peptides Derived from Mouse Liver and Spleen in Response to IFN-γ.
Kuraoka S, Higashi H, Yanagihara Y, Sonawane AR, Mukai S, Mlynarchik AK, Whelan MC, Hottiger MO, Nasir W, Delanghe B, Aikawa M, Singh SA. Kuraoka S, et al. Among authors: mlynarchik ak. Mol Cell Proteomics. 2022 Apr;21(4):100153. doi: 10.1016/j.mcpro.2021.100153. Epub 2021 Sep 28. Mol Cell Proteomics. 2022. PMID: 34592425 Free PMC article.
Systems Approach to Discovery of Therapeutic Targets for Vein Graft Disease: PPARα Pivotally Regulates Metabolism, Activation, and Heterogeneity of Macrophages and Lesion Development.
Decano JL, Singh SA, Gasparotto Bueno C, Ho Lee L, Halu A, Chelvanambi S, Matamalas JT, Zhang H, Mlynarchik AK, Qiao J, Sharma A, Mukai S, Wang J, Anderson DG, Ozaki CK, Libby P, Aikawa E, Aikawa M. Decano JL, et al. Among authors: mlynarchik ak. Circulation. 2021 Jun 22;143(25):2454-2470. doi: 10.1161/CIRCULATIONAHA.119.043724. Epub 2021 Apr 6. Circulation. 2021. PMID: 33821665 Free PMC article.
Dynamin-related protein 1 inhibition reduces hepatic PCSK9 secretion.
Rogers MA, Hutcheson JD, Okui T, Goettsch C, Singh SA, Halu A, Schlotter F, Higashi H, Wang L, Whelan MC, Mlynarchik AK, Daugherty A, Nomura M, Aikawa M, Aikawa E. Rogers MA, et al. Among authors: mlynarchik ak. Cardiovasc Res. 2021 Sep 28;117(11):2340-2353. doi: 10.1093/cvr/cvab034. Cardiovasc Res. 2021. PMID: 33523181 Free PMC article.
A single injection of gain-of-function mutant PCSK9 adeno-associated virus vector induces cardiovascular calcification in mice with no genetic modification.
Goettsch C, Hutcheson JD, Hagita S, Rogers MA, Creager MD, Pham T, Choi J, Mlynarchik AK, Pieper B, Kjolby M, Aikawa M, Aikawa E. Goettsch C, et al. Among authors: mlynarchik ak. Atherosclerosis. 2016 Aug;251:109-118. doi: 10.1016/j.atherosclerosis.2016.06.011. Epub 2016 Jun 9. Atherosclerosis. 2016. PMID: 27318830 Free PMC article.
Angiopoietin Like Protein 2 (ANGPTL2) Promotes Adipose Tissue Macrophage and T lymphocyte Accumulation and Leads to Insulin Resistance.
Sasaki Y, Ohta M, Desai D, Figueiredo JL, Whelan MC, Sugano T, Yamabi M, Yano W, Faits T, Yabusaki K, Zhang H, Mlynarchik AK, Inoue K, Mizuno K, Aikawa M. Sasaki Y, et al. Among authors: mlynarchik ak. PLoS One. 2015 Jul 1;10(7):e0131176. doi: 10.1371/journal.pone.0131176. eCollection 2015. PLoS One. 2015. PMID: 26132105 Free PMC article.