Miyashita SI - Search Results

1

Massively parallel de novo protein design for targeted therapeutics.

Chevalier A, Silva DA, Rocklin GJ, Hicks DR, Vergara R, Murapa P, Bernard SM, Zhang L, Lam KH, Yao G, Bahl CD, Miyashita SI, Goreshnik I, Fuller JT, Koday MT, Jenkins CM, Colvin T, Carter L, Bohn A, Bryan CM, Fernández-Velasco DA, Stewart L, Dong M, Huang X, Jin R, Wilson IA, Fuller DH, Baker D. Chevalier A, et al. Among authors: miyashita si. Nature. 2017 Oct 5;550(7674):74-79. doi: 10.1038/nature23912. Epub 2017 Sep 27. Nature. 2017. PMID: 28953867 Free PMC article.

2

Identification and characterization of a novel botulinum neurotoxin.

Zhang S, Masuyer G, Zhang J, Shen Y, Lundin D, Henriksson L, Miyashita SI, Martínez-Carranza M, Dong M, Stenmark P. Zhang S, et al. Among authors: miyashita si. Nat Commun. 2017 Aug 3;8:14130. doi: 10.1038/ncomms14130. Nat Commun. 2017. PMID: 28770820 Free PMC article.

3

Covalent Modifiers of Botulinum Neurotoxin Counteract Toxin Persistence.

Garland M, Babin BM, Miyashita SI, Loscher S, Shen Y, Dong M, Bogyo M. Garland M, et al. Among authors: miyashita si. ACS Chem Biol. 2019 Jan 18;14(1):76-87. doi: 10.1021/acschembio.8b00937. Epub 2019 Jan 8. ACS Chem Biol. 2019. PMID: 30571080 Free PMC article.

4

Sulfated glycosaminoglycans and low-density lipoprotein receptor contribute to Clostridium difficile toxin A entry into cells.

Tao L, Tian S, Zhang J, Liu Z, Robinson-McCarthy L, Miyashita SI, Breault DT, Gerhard R, Oottamasathien S, Whelan SPJ, Dong M. Tao L, et al. Among authors: miyashita si. Nat Microbiol. 2019 Oct;4(10):1760-1769. doi: 10.1038/s41564-019-0464-z. Epub 2019 Jun 3. Nat Microbiol. 2019. PMID: 31160825 Free PMC article.

5

Characterization of a membrane binding loop leads to engineering botulinum neurotoxin B with improved therapeutic efficacy.

Yin L, Masuyer G, Zhang S, Zhang J, Miyashita SI, Burgin D, Lovelock L, Coker SF, Fu TM, Stenmark P, Dong M. Yin L, et al. Among authors: miyashita si. PLoS Biol. 2020 Mar 17;18(3):e3000618. doi: 10.1371/journal.pbio.3000618. eCollection 2020 Mar. PLoS Biol. 2020. PMID: 32182233 Free PMC article.

6

Delivery of single-domain antibodies into neurons using a chimeric toxin-based platform is therapeutic in mouse models of botulism.

Miyashita SI, Zhang J, Zhang S, Shoemaker CB, Dong M. Miyashita SI, et al. Sci Transl Med. 2021 Jan 6;13(575):eaaz4197. doi: 10.1126/scitranslmed.aaz4197. Sci Transl Med. 2021. PMID: 33408184

7

Knockin mouse models demonstrate differential contributions of synaptotagmin-1 and -2 as receptors for botulinum neurotoxins.

Thaker H, Zhang J, Miyashita SI, Cristofaro V, Park S, Hashemi Gheinani A, Sullivan MP, Adam RM, Dong M. Thaker H, et al. Among authors: miyashita si. PLoS Pathog. 2021 Oct 18;17(10):e1009994. doi: 10.1371/journal.ppat.1009994. eCollection 2021 Oct. PLoS Pathog. 2021. PMID: 34662366 Free PMC article.

8

Functional Deimmunization of Botulinum Neurotoxin Protease Domain via Computationally Driven Library Design and Ultrahigh-Throughput Screening.

Fang Y, Chang AY, Verma D, Miyashita SI, Eszterhas S, Lee PG, Shen Y, Davis LR, Dong M, Bailey-Kellogg C, Griswold KE. Fang Y, et al. Among authors: miyashita si. ACS Synth Biol. 2023 Jan 20;12(1):153-163. doi: 10.1021/acssynbio.2c00426. Epub 2023 Jan 9. ACS Synth Biol. 2023. PMID: 36623275 Free PMC article.

9

Characterization of Serotype CD Mosaic Botulinum Neurotoxin in Comparison with Serotype C and A.

Miyashita SI, Karatsu S, Fujiishi M, Huang IH, Nagashima Y, Morobishi T, Hosoya K, Hata T, Dong M, Sagane Y. Miyashita SI, et al. Toxins (Basel). 2023 Feb 3;15(2):123. doi: 10.3390/toxins15020123. Toxins (Basel). 2023. PMID: 36828437 Free PMC article.

10

Identification of a Botulinum Neurotoxin-like Toxin in a Commensal Strain of Enterococcus faecium.

Zhang S, Lebreton F, Mansfield MJ, Miyashita SI, Zhang J, Schwartzman JA, Tao L, Masuyer G, Martínez-Carranza M, Stenmark P, Gilmore MS, Doxey AC, Dong M. Zhang S, et al. Among authors: miyashita si. Cell Host Microbe. 2018 Feb 14;23(2):169-176.e6. doi: 10.1016/j.chom.2017.12.018. Epub 2018 Jan 27. Cell Host Microbe. 2018. PMID: 29396040 Free PMC article.

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