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Intensity and duration of TCR signaling is limited by p38 phosphorylation of ZAP-70T293 and destabilization of the signalosome.
Giardino Torchia ML, Dutta D, Mittelstadt PR, Guha J, Gaida MM, Fish K, Barr VA, Akpan IO, Samelson LE, Tagad HD, Debnath S, Miller Jenkins LM, Appella E, Ashwell JD. Giardino Torchia ML, et al. Among authors: mittelstadt pr. Proc Natl Acad Sci U S A. 2018 Feb 27;115(9):2174-2179. doi: 10.1073/pnas.1713301115. Epub 2018 Feb 12. Proc Natl Acad Sci U S A. 2018. PMID: 29440413 Free PMC article.
Activating p38 MAPK: new tricks for an old kinase.
Mittelstadt PR, Salvador JM, Fornace AJ Jr, Ashwell JD. Mittelstadt PR, et al. Cell Cycle. 2005 Sep;4(9):1189-92. doi: 10.4161/cc.4.9.2043. Epub 2005 Sep 20. Cell Cycle. 2005. PMID: 16103752 Review.
The TBK1-binding domain of optineurin promotes type I interferon responses.
Meena NP, Zhu G, Mittelstadt PR, Giardino Torchia ML, Pourcelot M, Arnoult D, Ashwell JD, Munitic I. Meena NP, et al. Among authors: mittelstadt pr. FEBS Lett. 2016 May;590(10):1498-508. doi: 10.1002/1873-3468.12176. Epub 2016 May 4. FEBS Lett. 2016. PMID: 27086836 Free PMC article.
30 results