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Syrian hamsters as a small animal model for SARS-CoV-2 infection and countermeasure development.
Imai M, Iwatsuki-Horimoto K, Hatta M, Loeber S, Halfmann PJ, Nakajima N, Watanabe T, Ujie M, Takahashi K, Ito M, Yamada S, Fan S, Chiba S, Kuroda M, Guan L, Takada K, Armbrust T, Balogh A, Furusawa Y, Okuda M, Ueki H, Yasuhara A, Sakai-Tagawa Y, Lopes TJS, Kiso M, Yamayoshi S, Kinoshita N, Ohmagari N, Hattori SI, Takeda M, Mitsuya H, Krammer F, Suzuki T, Kawaoka Y. Imai M, et al. Among authors: mitsuya h. Proc Natl Acad Sci U S A. 2020 Jul 14;117(28):16587-16595. doi: 10.1073/pnas.2009799117. Epub 2020 Jun 22. Proc Natl Acad Sci U S A. 2020. PMID: 32571934 Free PMC article.
Design of Highly Potent, Dual-Acting and Central-Nervous-System-Penetrating HIV-1 Protease Inhibitors with Excellent Potency against Multidrug-Resistant HIV-1 Variants.
Ghosh AK, Rao KV, Nyalapatla PR, Kovela S, Brindisi M, Osswald HL, Sekhara Reddy B, Agniswamy J, Wang YF, Aoki M, Hattori SI, Weber IT, Mitsuya H. Ghosh AK, et al. Among authors: mitsuya h. ChemMedChem. 2018 Apr 23;13(8):803-815. doi: 10.1002/cmdc.201700824. Epub 2018 Mar 15. ChemMedChem. 2018. PMID: 29437300 Free PMC article.
GRL-079, a Novel HIV-1 Protease Inhibitor, Is Extremely Potent against Multidrug-Resistant HIV-1 Variants and Has a High Genetic Barrier against the Emergence of Resistant Variants.
Delino NS, Aoki M, Hayashi H, Hattori SI, Chang SB, Takamatsu Y, Martyr CD, Das D, Ghosh AK, Mitsuya H. Delino NS, et al. Among authors: mitsuya h. Antimicrob Agents Chemother. 2018 Apr 26;62(5):e02060-17. doi: 10.1128/AAC.02060-17. Print 2018 May. Antimicrob Agents Chemother. 2018. PMID: 29463535 Free PMC article.
A familial cluster of severe coronavirus disease 2019 that required intubation of all family members.
Katsuno T, Suzuki M, Ishikane M, Kinoshita N, Tsukada A, Morita C, Kusaba Y, Sakamoto K, Yamaguchi Y, Tsujimoto Y, Hashimoto M, Terada J, Takasaki J, Izumi S, Okuhama A, Ide S, Moriyama Y, Matsuda K, Takamatsu Y, Mitsuya H, Hojo M, Sugiyama H. Katsuno T, et al. Among authors: mitsuya h. Infect Dis (Lond). 2020 Oct;52(10):755-758. doi: 10.1080/23744235.2020.1784999. Epub 2020 Jul 2. Infect Dis (Lond). 2020. PMID: 32615051 No abstract available.
GRL-0920, an Indole Chloropyridinyl Ester, Completely Blocks SARS-CoV-2 Infection.
Hattori SI, Higshi-Kuwata N, Raghavaiah J, Das D, Bulut H, Davis DA, Takamatsu Y, Matsuda K, Takamune N, Kishimoto N, Okamura T, Misumi S, Yarchoan R, Maeda K, Ghosh AK, Mitsuya H. Hattori SI, et al. Among authors: mitsuya h. mBio. 2020 Aug 20;11(4):e01833-20. doi: 10.1128/mBio.01833-20. mBio. 2020. PMID: 32820005 Free PMC article.
Comparison of Rapid Antigen Tests for COVID-19.
Yamayoshi S, Sakai-Tagawa Y, Koga M, Akasaka O, Nakachi I, Koh H, Maeda K, Adachi E, Saito M, Nagai H, Ikeuchi K, Ogura T, Baba R, Fujita K, Fukui T, Ito F, Hattori SI, Yamamoto K, Nakamoto T, Furusawa Y, Yasuhara A, Ujie M, Yamada S, Ito M, Mitsuya H, Omagari N, Yotsuyanagi H, Iwatsuki-Horimoto K, Imai M, Kawaoka Y. Yamayoshi S, et al. Among authors: mitsuya h. Viruses. 2020 Dec 10;12(12):1420. doi: 10.3390/v12121420. Viruses. 2020. PMID: 33322035 Free PMC article.
A small molecule compound with an indole moiety inhibits the main protease of SARS-CoV-2 and blocks virus replication.
Hattori SI, Higashi-Kuwata N, Hayashi H, Allu SR, Raghavaiah J, Bulut H, Das D, Anson BJ, Lendy EK, Takamatsu Y, Takamune N, Kishimoto N, Murayama K, Hasegawa K, Li M, Davis DA, Kodama EN, Yarchoan R, Wlodawer A, Misumi S, Mesecar AD, Ghosh AK, Mitsuya H. Hattori SI, et al. Among authors: mitsuya h. Nat Commun. 2021 Jan 28;12(1):668. doi: 10.1038/s41467-021-20900-6. Nat Commun. 2021. PMID: 33510133 Free PMC article.
709 results