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A "two-hit" (chemo)therapy to improve checkpoint inhibition in cancer.
Falvo P, Orecchioni S, Raveane A, Mitola G, Bertolini F. Falvo P, et al. Among authors: mitola g. Oncoscience. 2021 May 7;8:55-57. doi: 10.18632/oncoscience.533. eCollection 2021. Oncoscience. 2021. PMID: 33997109 Free PMC article. No abstract available.
Metformin sensitizes leukemic cells to cytotoxic lymphocytes by increasing expression of intercellular adhesion molecule-1 (ICAM-1).
Allende-Vega N, Marco Brualla J, Falvo P, Alexia C, Constantinides M, de Maudave AF, Coenon L, Gitenay D, Mitola G, Massa P, Orecchioni S, Bertolini F, Marzo I, Anel A, Villalba M. Allende-Vega N, et al. Among authors: mitola g. Sci Rep. 2022 Jan 25;12(1):1341. doi: 10.1038/s41598-022-05470-x. Sci Rep. 2022. PMID: 35079096 Free PMC article.
The metabolism of cells regulates their sensitivity to NK cells depending on p53 status.
Belkahla S, Brualla JM, Fayd'herbe de Maudave A, Falvo P, Allende-Vega N, Constantinides M, Khan AUH, Coenon L, Alexia C, Mitola G, Massa P, Orecchioni S, Bertolini F, Mnif W, Hernandez J, Anel A, Villalba M. Belkahla S, et al. Among authors: mitola g. Sci Rep. 2022 Feb 25;12(1):3234. doi: 10.1038/s41598-022-07281-6. Sci Rep. 2022. PMID: 35217717 Free PMC article.